Genomic approaches to accelerate cancer interception.
Genomic approaches to accelerate cancer interception.
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DOI：
10.1016/s1470-2045(17)30373-x
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Spira A
中科院分区：
文献类型：
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作者：
Beane J;Campbell JD;Lel J;Vick J;Spira A
虽然在过去的十年中，靶向和基于免疫的疗法在治疗晚期癌症方面取得了重大进展，但开发新方法以影响癌症的预防和早期检测的关键需求尚未得到满足。基因组学和计算生物学领域的最新进展提供了前所未有的机会，以了解与癌变相关的最早的分子事件，导致新的策略来拦截侵袭性癌症的发展。本综述将重点介绍新兴的“大数据”基因组方法，这些方法有可能加速各种肿瘤类型的癌症预防，筛查和早期检测的进展，沿着开发这些工具用于临床的固有挑战。通过协调的多中心联盟，这些基因组方法有望在未来几年改变癌症拦截的格局。
While the last decade has witnessed major advances in the treatment of late stage cancers with targeted and immune-based therapies, there is a critical unmet need to develop new approaches to impact the prevention and early detection of cancer. Recent advances in the field of genomics and computational biology offer unprecedented opportunities to understand the earliest molecular events associated with carcinogenesis, leading to novel strategies to intercept the development of invasive cancers. This review will highlight emerging “big data” genomic approaches that have the potential to accelerate advances in cancer prevention, screening and early detection across a variety of tumor types along with the challenges inherent in developing these tools for use in the clinic. Through coordinated multicenter consortia, these genomic approaches promise to transform the landscape of cancer interception in the coming years.