Detection of an autoantibody directed against human liver microsomal protein in a patient with carbamazepine hypersensitivity.
Detection of an autoantibody directed against human liver microsomal protein in a patient with carbamazepine hypersensitivity.
复制标题
卡马西平过敏患者体内针对人肝微粒体蛋白的自身抗体的检测。
DOI：
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发表时间：
1992
影响因子：
3.4
通讯作者：
B. Park
中科院分区：
文献类型：
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作者：
M. Pirmohamed;N. Kitteringham;Alasdair M Breckenridge;B. Park
一名 16 岁患者患有卡马西平引起的肝毒性，并伴有发烧、皮疹和嗜酸性粒细胞增多等超敏反应表现。与对照细胞相比，患者的单核白细胞对诱导小鼠和人肝微粒体产生的卡马西平氧化代谢物更敏感。在免疫印迹分析中，患者血清在人肝微粒体上识别出单个蛋白条带 (94 kDa)，但 25 份对照血清中没有一个识别出该条带。人肾微粒体或小鼠和大鼠肝脏微粒体上的患者血清未识别出条带。
A 16-year old patient with carbamazepine-induced hepatotoxicity, associated with the hypersensitivity manifestations of fever, rash and eosinophilia, is described. Mononuclear leucocytes from the patient were more sensitive to oxidative metabolites of carbamazepine generated by induced murine and human hepatic microsomes, than cells from controls. On immunoblot analysis, serum from the patient recognised a single protein band (94 kDa) on human liver microsomes, but none out of 25 control sera recognised this band. No bands were recognised by the patient serum on human kidney microsomes or on microsomes from mouse and rat liver.