Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2.
Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2.
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肌醇六磷酸受体被鉴定为网格蛋白组装蛋白 AP-2。
DOI：
10.1016/s0006-291x(05)81473-1
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发表时间：
1992
影响因子：
3.1
通讯作者：
Theibert,AB
中科院分区：
文献类型：
--
作者：
Voglmaier,SM;Keen,JH;Murphy,JE;Ferris,CD;Prestwich,GD;Snyder,SH;Theibert,AB
为了阐明肌醇六磷酸（IP 6）受体结合蛋白的功能，我们从纯化的蛋白质中获得了部分氨基酸序列，并从该基因的cDNA克隆中获得了部分核苷酸序列。这些序列与网格蛋白组装蛋白AP-2的α亚基的序列基本相同。经SDS-PAGE分析，IP 6受体蛋白含有一系列与AP-2相同的亚基。AP-2抗体在免疫印迹分析中与IP 6受体蛋白反应。
To clarify the function of the receptor binding protein for inositol hexakisphosphate (IP6), we obtained a partial amino acid sequence from the purified protein and a partial nucleotide sequence from a cDNA clone of the gene. The sequences are essentially identical to those of theα-subunit of the clathrin assembly protein AP-2. The IP6receptor protein analyzed by SDS-PAGE contains a series of subunits which are the same as those of AP-2. Antibodies to AP-2 react with the IP6receptor protein in immunoblot analysis.