Cholinergic and GABAergic modulation of medial septal area: effect on working memory.
Cholinergic and GABAergic modulation of medial septal area: effect on working memory.
复制标题
DOI：
10.1037//0735-7044.104.6.849
复制
发表时间：
1990-12
影响因子：
1.9
通讯作者：
Ben Givens;D. Olton
中科院分区：
文献类型：
--
作者：
Ben Givens;D. Olton
通过向内侧隔区（MSA）直接微量输注化合物，研究隔-海马通路在工作记忆中的作用。通过在T迷宫中连续空间改变任务中的表现来测量行为，并且还记录海马θ节律。间隔内生理盐水对选择准确性或海马θ节律没有影响。丁卡因在输注后10 min降低了选择准确性和θ节律，但在输注后90 min未降低。同样，蝇蕈醇和东莨菪碱产生短暂的，剂量依赖性抑制海马θ节律和同时剂量依赖性损害的选择准确性。一个显着的相关性（r = 0.78）之间出现的化合物的影响θ节奏和它的影响选择的准确性。这些数据支持隔海马投射在工作记忆中的作用，并表明γ-氨基丁酸和乙酰胆碱可能对MSA中的神经元产生相反的影响。
The role of the septohippocampal pathway in working memory was investigated by direct microinfusion of compounds into the medial septal area (MSA). Behavior was measured by performance in a continuous spatial alteration task in a T maze, and hippocampal theta rhythm was also recorded. Intraseptal saline had no effect on choice accuracy or hippocampal theta rhythm. Tetracaine decreased choice accuracy and theta rhythm 10 min, but not 90 min, after infusion. Likewise, muscimol and scopolamine produced a transient, dose-dependent suppression of hippocampal theta rhythm and a simultaneous dose-dependent impairment in choice accuracy. A significant correlation (r = .78) emerged between a compound's influence on theta rhythm and its effect on choice accuracy. The data support a role for the septohippocampal projection in working memory and suggest that gamma-aminobutyric acid and acetylcholine may have opposing influences on neurons in the MSA.