Chemical constituents of Garcinia fusca:: Structure elucidation of eight new xanthones and their cancer chemopreventive activity
Chemical constituents of Garcinia fusca:: Structure elucidation of eight new xanthones and their cancer chemopreventive activity
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DOI：
10.1021/np020290s
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发表时间：
2003-02-01
影响因子：
5.1
通讯作者：
Furukawa, H
中科院分区：
文献类型：
--
作者：
Ito, C;Itoigawa, M;Furukawa, H
本文报道了从泰国藤黄茎皮中分离得到8个新的黄酮A(1)、B(2)、C(3)、D(4)、E(5)、F(6)、G(7)和H(8)，以及8个已知黄酮的分离和光谱结构分析。所有的新山酮在分子中都有一个萜类（戊烯基和/或香叶基）侧链。我们还介绍了作为该植物主要成分的8种山酮（9-16）对Raji细胞中12- o - tetradecanoylphorbol13 -acetate诱导的Epstein-Barr病毒早期抗原激活的抑制作用的初步筛选结果。
We describe the isolation and spectrometric structure elucidation of eight new xanthones, fuscaxanthone A (1), B (2), C (3), D (4), E (5), F (6), G (7), and H (8), together with eight known xanthones from the stem bark of Garcinia fusca collected in Thailand. All the new xanthones were shown to have a terpenoid (prenyl and/or geranyl) side chain(s) in their molecules. We also present the results of a primary screening of the inhibitory effects of eight xanthones (9-16) isolated as major components of this plant on 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation in Raji cells.