A neural modeling approach to study mechanisms underlying the heterogeneity of visual spatial frequency sensitivity in schizophrenia.
A neural modeling approach to study mechanisms underlying the heterogeneity of visual spatial frequency sensitivity in schizophrenia.
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一种神经建模方法，用于研究精神分裂症视觉空间频率敏感性异质性的机制。
DOI：
10.1101/2023.10.18.563001
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Yazdanbakhsh,Arash
中科院分区：
文献类型：
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作者：
Dugan,Caroline;Zikopoulos,Basilis;Yazdanbakhsh,Arash
精神分裂症患者表现出空间频率敏感性的异常，人们认为这些异常表明自下而上处理的更广泛的功能障碍和失调。早期视觉系统，包括丘脑一阶外侧膝状体核（LGN）和初级视觉皮层（V1），是空间频率敏感性的关键贡献者。药物治疗和未治疗的精神分裂症患者表现出空间频率敏感性的对比变化，从而使其成为一个有用的探针，检查潜在的影响的障碍和抗精神病药物在神经处理。我们构建了一个参数化的，基于速率的神经模型上的中心/离周围的神经元在早期视觉系统中的兴奋性和抑制性感受野子字段的变化的影响进行调查。通过将与精神分裂症的病理生理学发现相关的兴奋性和抑制性子字段的变化，该模型成功地复制了涉及药物治疗和未治疗患者的行为/功能研究的感知数据。在几个合理的机制中，我们的研究结果突出了抑制的兴奋和/或增加的传播和强度的抑制子域在用药患者和对比减少的传播和强度的抑制在未用药的患者。鉴于该模型在各种条件下成功地复制了感知数据的结果，这些感受野的元素可能是精神分裂症患者中观察到的不平衡的有用标记。
Patients with schizophrenia exhibit abnormalities in spatial frequency sensitivity, and it is believed that these abnormalities indicate more widespread dysfunction and dysregulation of bottom-up processing. The early visual system, including the first-order Lateral Geniculate Nucleus of the thalamus (LGN) and the primary visual cortex (V1), are key contributors to spatial frequency sensitivity. Medicated and unmedicated patients with schizophrenia exhibit contrasting changes in spatial frequency sensitivity, thus making it a useful probe for examining potential effects of the disorder and antipsychotic medications in neural processing. We constructed a parameterized, rate-based neural model of on-center/off-surround neurons in the early visual system to investigate the impacts of changes to the excitatory and inhibitory receptive field subfields. By incorporating changes in both the excitatory and inhibitory subfields that are associated with pathophysiological findings in schizophrenia, the model successfully replicated perceptual data from behavioral/functional studies involving medicated and unmedicated patients. Among several plausible mechanisms, our results highlight the dampening of excitation and/or increase in the spread and strength of the inhibitory subfield in medicated patients and the contrasting decreased spread and strength of inhibition in unmedicated patients. Given that the model was successful at replicating results from perceptual data under a variety of conditions, these elements of the receptive field may be useful markers for the imbalances seen in patients with schizophrenia.