Lung cancer in patients with idiopathic pulmonary fibrosis: CT findings
Lung cancer in patients with idiopathic pulmonary fibrosis: CT findings
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DOI：
10.1097/00004728-199611000-00020
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发表时间：
1996-11-01
影响因子：
1.3
通讯作者：
Yeon, KM
中科院分区：
文献类型：
--
作者：
Lee, HJ;Im, JG;Yeon, KM
目的：特发性肺纤维化（IPF）患者患肺癌的频率高于一般人群。为了评估与IPF相关的肺癌的CT表现，我们分析了32例与IPF相关的肺癌患者。方法：我们回顾性分析了244例通过CT和临床表现（n = 220）或组织学（n = 24）诊断为IPF的连续病例中的32例经组织学确诊的肺癌患者。患者年龄40-85岁（平均66岁，M/F = 31/1）。扫描技术为常规CT（24例）、高分辨率CT（HRCT）2例、常规CT+HRCT（6例）。我们分析了肺癌的CT表现、部位和组织学类型。结果：IPF患者中肺癌的发生率为13.1%（32/244）。 32 名患者中有 17 名的肺癌 CT 表现是边界不清的病灶，类似于气腔实变。肺癌主要位于下叶（21/32）和周围部分（21/32）。组织学上，鳞状细胞癌最为常见（18/32）。结论：肺癌的典型CT表现是周围部分边界不清的实变样肿块，纤维化最严重的部位。
Purpose: The frequency of lung cancer in patients with idiopathic pulmonary fibrosis (IPF) is higher than that of general population. To evaluate CT findings of lung cancer associated with IPF, we analyzed 32 patients with lung cancer associated with IPF.Method: We analyzed retrospectively 32 patients with histologically confirmed lung cancer out of 244 consecutive cases diagnosed as IPF by either CT and clinical findings (n = 220) or histologically (n = 24). The patients were 40-85 years old (mean 66 years, M/F = 31/1). Scanning techniques were conventional CT in 24 patients, high resolution CT (HRCT) in 2 patients, and both conventional CT and HRCT in 6 patients. We analyzed the CT patterns, locations, and histologic types of lung cancer.Results: The frequency of lung cancer in patients with IPF was 13.1% (32/244). In 17 of 32 patients, the CT findings of lung cancer were ill defined lesions mimicking air-space consolidation. Lung cancer was located mainly in the lower lobes (21/32) and peripheral portion (21/32). Histologically, squamous cell carcinoma was the most common type (18/32).Conclusion: Typical CT findings of lung cancer were ill defined consolidation-like masses at the peripheral portion where the most advanced fibrosis was located.