RACIAL PATTERNS IN PERNICIOUS-ANEMIA - EARLY AGE AT ONSET AND INCREASED FREQUENCY OF INTRINSIC-FACTOR ANTIBODY IN BLACK WOMEN
RACIAL PATTERNS IN PERNICIOUS-ANEMIA - EARLY AGE AT ONSET AND INCREASED FREQUENCY OF INTRINSIC-FACTOR ANTIBODY IN BLACK WOMEN
复制标题
DOI：
10.1056/nejm197803232981203
复制
发表时间：
1978-01-01
影响因子：
158.5
通讯作者：
JOHNSON, CS
中科院分区：
文献类型：
--
作者：
CARMEL, R;JOHNSON, CS
恶性贫血主要影响老年北方欧洲人，但可能比以前认为的更经常影响其他人。分析了156例记录病例的数据;有73例欧洲患者，52例黑人患者和31例拉丁美洲患者。平均年龄（. ±. 1 SD）在黑人妇女中，53 .+-。16岁的黑人女性中，年龄小于40岁的有7例（P < 0.001）。此外，24名黑人妇女中有23人有内因子循环抗体。类似但不太引人注目的抗体流行率（85%）和年龄模式（60 ± 10岁）。13岁），在拉丁美洲妇女没有达到统计学意义。没有其他群体超过通常的55-70%的抗体流行率。这些发现表明，在黑人妇女，也许在拉丁美洲妇女中，对这种疾病有不同的形式或不同的反应。
Pernicious anemia affects primarily elderly northern Europeans, but may affect others more often than previously thought. Data from 156 documented cases were analyzed; there were 73 patients of European origin, 52 black patients and 31 Latin-American patients. The mean age (.+-. 1 SD) at presentation among black women, 53 .+-. 16 yr, was lower than that of all the others (P < 0.001 in most comparisons), and 7 of the 33 black women were less than 40 yr old. In addition, 23 of the 24 black women tested had circulating antibody to intrinsic factor. A similar though less striking antibody prevalence (85%) and age pattern (60 .+-. 13 yr) in Latin-American women did not reach statistical significance. No other group exceeded the usual 55-70% prevalence of antibody. These findings suggest a different form of or a different response to the disease in black women and perhaps in Latin-American women.