Local atopy is more relevant than serum sIgE in reflecting allergy in childhood adenotonsillar hypertrophy
Local atopy is more relevant than serum sIgE in reflecting allergy in childhood adenotonsillar hypertrophy
复制标题
局部特应性比血清 sIgE 更能反映儿童腺样体肥大的过敏情况
DOI：
10.1111/pai.12089
复制
发表时间：
2013-08-01
影响因子：
4.4
通讯作者：
Zeng, Guangqiao
中科院分区：
文献类型：
--
作者：
Zhang, Xiaowen;Sun, Baoqing;Zeng, Guangqiao
背景过敏症对腺扁桃体肥大(ATH)的影响缺乏令人信服的证据。方法采用Pharmacia免疫CAP系统检测83例儿童扁桃体切除术前血清及扁桃体组织中31种变应原的特异性IgE。结果共检出51例(61.45%)儿童血清sIgE阳性。20例ATH患儿的扁桃体和腺样体中均有两种以上变应原sIgE阳性，但其中半数为sIgE阴性。血清sIgE表达阳性者中，腺样体和扁桃体sIgE表达阳性者分别为50.0%和42.9%。在血清sIgE表达阴性的患者中，36.0%的腺样体和43.8%的扁桃体检出局部sIgE。局部组织(腺样体或扁桃体)中sIgE的阳性率明显高于血清中的sIgE。结论本研究提供了变态反应性炎症在ATH中起重要作用的证据。腺体和血清中sIgE表达的不一致提示局部特应性在儿童ATH中的作用。
BackgroundThere was a lack of convincing evidence supporting the influence of allergy on the adenotonsillar hypertrophy (ATH). We investigated the presence of specific IgE (sIgE) in the serum and adenotonsillar tissues in children with ATH.MethodsA Pharmacia ImmunoCAP system was used to test sIgE against 31 allergens in the serum in 83 children with ATH before adenotonsillectomy. sIgE against 15 representative allergens were detected in adenotonsillar tissues from 20 of those children.ResultsA total of 51 (61.45%) children had positive serum sIgE. 20 children with ATH had positive sIgE to more than two allergens at both tonsils and adenoids, although half of them were serum sIgE negative. The percentage of subjects with positive sIgE expression in adenoids and tonsils was 50.0% and 42.9%, respectively, among the subjects with positive serum sIgE expression. Of subjects with negative serum sIgE expression, local sIgE was detected in 36.0% of adenoids and 43.8% of tonsils, respectively. The rate of sIgE presence in local tissue (adenoids or tonsils) was significantly higher than that seen in the serum.ConclusionThis study provided evidence that there was an important role for allergic inflammation in the ATH. The inconsistency in sIgE expression between adenotonsillar and serum suggests a role of local atopy in childhood ATH.