Once Is Too Much: Conditioned Aversion Develops Immediately and Predicts Future Cocaine Self-Administration Behavior in Rats
Once Is Too Much: Conditioned Aversion Develops Immediately and Predicts Future Cocaine Self-Administration Behavior in Rats
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DOI：
10.1037/a0036264
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发表时间：
2014-04-01
影响因子：
1.9
通讯作者：
Grigson, Patricia S.
中科院分区：
文献类型：
--
作者：
Colechio, Elizabeth M.;Imperio, Caesar G.;Grigson, Patricia S.
大鼠发出厌恶性味觉反应（TR）行为（即，在训练结束时，口内递送可卡因配对的味觉提示和更大的条件性厌恶TR后，口内递送可卡因配对的味觉提示和更大的条件性厌恶TR预测了更大的药物寻求和服用。在这里，我们研究了这种条件性厌恶TR行为的发展，在一个试验的基础上，努力确定行为的变化何时发生，以及这种行为的早期变化是否可以用来预测以后的药物服用。结果表明，对可卡因配对线索的条件厌恶TR在训练中很早就发生了（即，在少至1-2个味觉-药物配对之后），并且重要的是，它可以用于预测大鼠中以后的药物寻求和药物服用。
Rats emit aversive taste reactivity (TR) behavior (i.e., gapes) following intraoral delivery of a cocaine-paired taste cue and greater conditioned aversive TR at the end of training predicts greater drug-seeking and taking. Here, we examined the development of this conditioned aversive TR behavior on a trial-by-trial basis in an effort to determine when the change in behavior occurs and whether early changes in this behavior can be used to predict later drug taking. The results show that conditioned aversive TR to a cocaine-paired cue occurs very early in training (i.e., following as few as 1-2 taste-drug pairings) and, importantly, that it can be used to predict later drug seeking and drug taking in rats.