Convergence of neurotransmissions at synapse on IEG regulation in nucleus.
Convergence of neurotransmissions at synapse on IEG regulation in nucleus.
复制标题
DOI：
10.2741/4533
复制
发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
M. Fukuchi;M. Tsuda
中科院分区：
文献类型：
--
作者：
M. Fukuchi;M. Tsuda
毫无疑问，突触活性调节的即刻早期基因(IEGs)的表达有助于神经功能的长期变化，包括学习和记忆。因此，IEG表达的失调参与了神经和精神疾病以及认知功能障碍的发生。这主要是通过转基因动物模型和神经药理学分析来证明的。最近对IEG表达的调控机制进行了研究，并再次强调了IEG表达在可塑性相关过程中的作用，以及阐明了神经和精神疾病的分子机制和药物靶点。本文综述了IEG调节的最新研究，包括我们对兴奋性和调节性神经传递调节IEG表达的研究结果。此外，我们提出了IEG调节在神经和精神障碍以及长期神经功能中的可能作用。这篇综述加深了我们对IEG调节与神经功能和疾病之间关系的理解，并可能促进发现治疗精神障碍的新药物靶点。
There is no doubt that synaptic activity-regulated expression of immediate early genes (IEGs) contributes to long-lasting changes in neural functions, including learning and memory. Consequently, dysregulation of IEG expression has been involved in the conditions of neural and psychiatric disorders and cognitive dysfunction. This has mainly been demonstrated using genetically modified animal models and neuropharmacological analyses. The regulatory mechanisms of IEG expression have been investigated recently and have re-emphasized the role of IEG expression in plasticity-related processes as well as elucidating molecular mechanisms and drug targets for neurological and psychiatric disorders. This review summarizes recent studies of IEG regulation, including our findings of IEG expression regulated by excitatory and modulatory neurotransmissions. In addition, we propose possible roles for IEG regulation in neurological and psychiatric disorders and long-lasting neural functions. This review improves our understanding of the association between IEG regulation and neural function and diseases, and may promote the discovery of novel drug targets for psychiatric disorders.