Adiposity and fat distribution in relation to inflammation and oxidative stress in a relatively lean population of Chinese women.
Adiposity and fat distribution in relation to inflammation and oxidative stress in a relatively lean population of Chinese women.
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DOI：
10.3233/dma-130969
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Yang G
中科院分区：
文献类型：
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作者：
Wu SH;Shu XO;Chow WH;Xiang YB;Zhang X;Cai Q;Li HL;Milne G;Wen W;Ji BT;Rothman N;Gao YT;Zheng W;Yang G
目的：本研究评估了一组相对偏瘦的中国女性人群中各种肥胖人体测量指标与炎症和氧化应激标志物的相关性。方法：该分析包括1,005名40-70岁的中国女性。测量炎症和氧化应激标志物的血浆浓度。人体测量是由受过训练的面试官。结果如下：体重指数（BMI）、腰围（WC）和腰高比（WHtR）均与炎症标志物CRP、TNF-α、可溶性TNF-受体1（sTNF-R1）和IL-6呈正线性相关。肥胖的这些测量与氧化应激标志物F2-IsoP-M（F2-IsoPs的代谢物）显著正相关，但与F2-IsoPs无关。人体测量的极端四分位数之间的生物标志物差异很大，从sTNF-R1的9.7%到CRP的162.0%不等。对于每种特定的生物标志物，各种人体测量显示出类似的解释生物标志物变化的能力，CRP观察到最大的部分r2（11%）。结论：这项研究表明，在相对较瘦的中国女性中，全身性肥胖（以BMI测量）和中心性肥胖（以WC和WHtR测量）与各种炎症和氧化应激标志物呈正相关。F2-IsoPs的代谢产物F2-IsoP-M可能是比其母体化合物更好的体内氧化应激标志物。
Objectives: This study evaluated associations of various anthropometric measures of adiposity with a panel of inflammatory and oxidative stress markers in a relatively lean population of Chinese women. Methods: This analysis included 1,005 Chinese women aged 40–70 years. Plasma concentrations of inflammatory and oxidative stress markers were measured. Anthropometric measurements were taken by trained interviewers. Results: Body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) were all positively and linearly associated with the inflammatory markers, CRP, TNF-α, soluble TNF-receptor 1 (sTNF-R1), and IL-6. A significant positive association of these measures of adiposity with the oxidative stress marker F2-IsoP-M, a metabolite of F2-IsoPs, but with not F2-IsoPs was found. Differences in biomarkers between extreme quartiles of anthropometric measurements varied widely, ranging from 9.7% for sTNF-R1 to 162.0% for CRP. For each specific biomarker, various anthropometric measurements exhibited similar ability to explain variations in the biomarker, with the biggest partial r2 (11%) observed for CRP. Conclusions: This study suggests that both general adiposity (measured by BMI) and central adiposity (measured by WC and WHtR) are positively and similarly associated with various markers of inflammation and oxidative stress in relatively lean Chinese women. The metabolite F2-IsoP-M of F2-IsoPs may be a better marker of in vivo oxidative stress than its parent compounds.