Functional probe for annulus fibrosus-targeted intervertebral disc degeneration imaging.
Functional probe for annulus fibrosus-targeted intervertebral disc degeneration imaging.
复制标题
用于纤维环靶向椎间盘退变成像的功能探针。
DOI：
10.1117/1.jbo.18.10.101308
复制
发表时间：
2013
影响因子：
3.5
通讯作者：
Bai,Mingfeng
中科院分区：
文献类型：
--
作者：
Kim,Hye-Yeong;Mcclincy,Michael;Vo,NamV;Sowa,GwendolynA;Kang,JamesD;Bai,Mingfeng
Intervertebral disc degeneration (IDD) is closely associated with low back pain. Typically nonsurgical treatment of IDD is the most effective when detected early. As such, establishing reliable imaging methods for the early diagnosis of disc degeneration is critical. The cellular and tissue localization of a facile functional fluorescent probe, HYK52, that labels disc annulus fibrosus is reported. HYK52 was synthesized with high yield and purity via a two-step chemical reaction. Rabbit disc cell studies andex vivotissue staining images indicated intracellular localization and intervertebral disc (IVD) tissue binding of HYK52 with negligible cytotoxicity. Moreover, HYK52 is purposefully designed with a functional terminal carboxyl group to allow for coupling with various signaling molecules for multimodal imaging applications. These results suggest that this IVD-targeted probe may have great potential in early diagnosis of IDD.
