In Vitro Testing of an Implantable Wireless Telemetry System for Long-Term Electromyography Recordings in Large Animals
In Vitro Testing of an Implantable Wireless Telemetry System for Long-Term Electromyography Recordings in Large Animals
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DOI：
10.1111/aor.12626
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发表时间：
2015-10-01
影响因子：
2.4
通讯作者：
Mayr, Winfried
中科院分区：
文献类型：
--
作者：
Kneisz, Lukas;Unger, Ewald;Mayr, Winfried
在不受干扰的体内条件下的多通道生物信号记录是用于开发功能性电刺激（FES）应用、肢体假体和诊断工具的方法和相关设备的实验工作中的常见需求。肌内肌电图（EMG）记录可以在运动任务期间提供对激动性和拮抗性肌肉的复杂相互作用的全面了解，并且相反地作为神经假体和机械假体的可靠控制信号。我们制造了一个完全可植入的设备，它能够记录来自体内的肌电图信号，并将这些信号无线传输到外部接收器。所开发的模拟前端每个通道仅使用两个电极，提供60dB的增益，并包含具有4Hz的下限截止频率和480Hz的上限截止频率的带通滤波器。双向无线数据链路工作在2.4GHz工业、科学和医疗频段，设计用于10米的传输距离，两个通道中的每个通道的应用数据速率为1 kSps。使用环氧树脂涂层的器械进行体外测试，并插入具有组织等效特性的体模中，证实了我们概念的功能性，测量结果与之前模拟的结果一致。
Multichannel bio-signal recording in undisturbed in vivo conditions is a frequent demand in experimental work for development of methodology and associated equipment for functional electrical stimulation (FES) application, limb prosthesis, and diagnostic tools in contemporary rehabilitation efforts. Intramuscular electromyogram (EMG) recordings can provide comprehensive insight in complex interactions of agonistic and antagonistic muscles during movement tasks and in contrast act as reliable control signals for both neuroprosthesis and mechanical prosthesis. We fabricated a fully implantable device, which is capable of recording electromyography signals from inside a body and transmit these signals wirelessly to an external receiver. The developed analog front end uses only two electrodes per channel, provides a gain of 60dB, and incorporates a band pass filter with lower cut-off frequency of 4Hz and upper cut-off frequency of 480Hz. The bidirectional wireless data link, which operates in the 2.4GHz Industrial, Scientific and Medical band, is designed for transmission distances of 10 m using an application data rate of 1 kSps for each of the two channels. Performed in vitro tests with the devices coated in epoxy resin and inserted into a phantom with tissue-equivalent characteristics confirmed the functionality of our concept and the measurement results are consistent with those from preceding simulations.