Optimal time scale for spike-time reliability:: Theory, simulations, and experiments
Optimal time scale for spike-time reliability:: Theory, simulations, and experiments
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DOI：
10.1152/jn.00563.2007
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发表时间：
2008-01-01
影响因子：
2.5
通讯作者：
Urban, Nathaniel N.
中科院分区：
文献类型：
--
作者：
Galan, Roberto F.;Ermentrout, G. Bard;Urban, Nathaniel N.
使用尖峰定时来编码信息要求神经元以高时间精度和高可靠性响应。已知快速波动的刺激会导致试验中高度可重复的尖峰时间，而恒定的刺激会导致可变的尖峰时间。在这里，我们首先从数学上研究了尖峰时间可靠性如何依赖于非周期性刺激的快速性。然后，我们在计算机模拟神经元模型（Hodgkin-Huxley和改进的二次积分和激发）以及用真实的神经元（嗅球中的僧帽细胞和新皮层中的锥体细胞）进行的膜片钳实验中测试了我们的理论预测。正如我们的理论所预测的那样，我们发现，对于β/γ范围内的发射频率，当输入波动的时间尺度（自相关时间）在几毫秒（2-5 ms）的范围内时，尖峰时间可靠性最大，与快速突触的时间尺度一致，并且对于更快和更慢的输入大幅降低。最后，我们评论这些发现如何与机制引起神经元同步。
Use of spike timing to encode information requires that neurons respond with high temporal precision and with high reliability. Fast fluctuating stimuli are known to result in highly reproducible spike times across trials, whereas constant stimuli result in variable spike times. Here, we first studied mathematically how spike-time reliability depends on the rapidness of aperiodic stimuli. Then, we tested our theoretical predictions in computer simulations of neuron models (Hodgkin-Huxley and modified quadratic integrate-and-fire), as well as in patch-clamp experiments with real neurons (mitral cells in the olfactory bulb and pyramidal cells in the neocortex). As predicted by our theory, we found that for firing frequencies in the beta/gamma range, spike-time reliability is maximal when the time scale of the input fluctuations (autocorrelation time) is in the range of a few milliseconds (2-5 ms), coinciding with the time scale of fast synapses, and decreases substantially for faster and slower inputs. Finally, we comment how these findings relate to mechanisms causing neuronal synchronization.