Streptococcus pneumoniae: Invasion and Inflammation
Streptococcus pneumoniae: Invasion and Inflammation
复制标题
DOI：
10.1128/microbiolspec.gpp3-0004-2018
复制
发表时间：
2019-03-01
影响因子：
3.7
通讯作者：
Tuomanen, Elaine, I
中科院分区：
文献类型：
--
作者：
Loughran, Allister J.;Orihuela, Carlos J.;Tuomanen, Elaine, I
肺炎链球菌（肺炎球菌）是中耳炎、社区获得性肺炎和细菌性脑膜炎的主要原因。肺炎球菌的成功源于其作为共生菌在人群中持续存在并避免被免疫系统杀死的能力。本章首先回顾了肺炎球菌定植并从一个解剖部位传播到下一个部位的分子机制。然后，讨论了新发和经典肺炎球菌感染期间的炎症和细胞毒性机制。
Streptococcus pneumoniae (the pneumoccus) is the leading cause of otitis media, community-acquired pneumonia, and bacterial meningitis. The success of the pneumococcus stems from its ability to persist in the population as a commensal and avoid killing by immune system. This chapter first reviews the molecular mechanisms that allow the pneumococcus to colonize and spread from one anatomical site to the next. Then, it discusses the mechanisms of inflammation and cytotoxicity during emerging and classical pneumococcal infections.