Peroxisomal Dysfunction in Age-Related Diseases.
Peroxisomal Dysfunction in Age-Related Diseases.
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DOI：
10.1016/j.tem.2016.12.003
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Lodhi IJ
中科院分区：
文献类型：
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作者：
Cipolla CM;Lodhi IJ
过氧化物酶体执行许多与脂质和活性氧(ROS)代谢相关的关键功能。由过氧酶体功能受损或缺乏过氧酶体引起的破坏性遗传疾病的存在，突显了过氧酶体对人类健康的根本重要性。新的研究表明，过氧化体功能也可能随着年龄的增长而改变，并参与多种疾病的发病机制，包括糖尿病及其相关并发症、神经退行性疾病和癌症。随着越来越多的证据将过氧化物体功能障碍与这些获得性疾病的发病机制联系起来，在疾病预防或治疗中靶向过氧化物体功能的可能性变得有趣起来。在这里，我们回顾了最新的进展，以了解在遗传性过氧素体疾病的背景下，过氧素体功能障碍的病理生理学意义。
Peroxisomes carry out many key functions related to lipid and reactive oxygen species (ROS) metabolism. The fundamental importance of peroxisomes for health in humans is underscored by the existence of devastating genetic disorders caused by impaired peroxisomal function or lack of peroxisomes. Emerging studies suggest that peroxisomal function may also be altered with aging and contribute to the pathogenesis of a variety of diseases, including diabetes and its related complications, neurodegenerative disorders, and cancer. With increasing evidence connecting peroxisomal dysfunction to the pathogenesis of these acquired diseases, the possibility of targeting peroxisomal function in disease prevention or treatment becomes intriguing. Here, we review recent developments in understanding the pathophysiological implications of peroxisomal dysfunctions outside the context of inherited peroxisomal disorders.