Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder
Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder
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DOI：
10.1002/(sici)1096-9926(199711)56:5
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发表时间：
1997-11-01
期刊：
影响因子：
--
通讯作者：
Graham, JM
中科院分区：
文献类型：
--
作者：
Sampson, PD;Streissguth, AP;Graham, JM
我们对已发表的胎儿酒精综合征（FAS）的发病率进行了评论，并对FAS的发病率和酒精相关神经发育障碍（ARND）的患病率进行了新的估计。我们首先回顾了有效估计FAS发生率所需的标准，报告了最符合这些标准的三项基于人群的研究的估计值，并对高度暴露病例的不确定性进行了调整。因此，1975年在西雅图，FAS的发病率估计至少为2.8/1000活产，1979-81年在克利夫兰，类似于4.6/1000。在法国鲁贝（1977-1990年期间的数据），发病率在1.3/1，000至4.8/1，000之间，取决于用作诊断标准的影响的严重程度。利用纵向神经行为数据库的西雅图的研究，我们提出了一个可操作的医学研究所最近的定义ARND和估计其患病率在西雅图的1975年至1981年期间。因此，FAS和ARND的合并率估计至少为9.1/1，000。这个保守的比率--几乎每100个活产婴儿中就有一个--证实了许多卫生专业人员的看法，即胎儿接触酒精是一个严重的问题。(C)1997 Wiley-Liss，Inc.
We critique published incidences for fetal alcohol syndrome (FAS) and present new estimates of the incidence of FAS and the prevalence of alcohol-related neurodevelopmental disorder (ARND). We first review criteria necessary for valid estimation of FAS incidence, Estimates for three population-based studies that best meet these criteria are reported with adjustment for underascertainment of highly exposed cases. As a result, in 1975 in Seattle, the incidence of FAS can be estimated as at least 2.8/1000 live births, and for 1979-81 in Cleveland, similar to 4.6/1,000. In Roubaix, France (for data covering periods from 1977-1990), the rate is between 1.3 and 4.8/1,000, depending on the severity of effects used as diagnostic criteria. Utilizing the longitudinal neurobehavioral database of the Seattle study, we propose an operationalization of the Institute of Medicine's recent definition of ARND and estimate its prevalence in Seattle for the period 1975-1981. The combined rate of FAS and ARND is thus estimated to be at least 9.1/1,000. This conservative rate-nearly one in every 100 live births-confirms the perception of many health professionals that fetal alcohol exposure is a serious problem. (C) 1997 Wiley-Liss, Inc.