Effect of ascorbate on the toxicity of morphine in mice
Effect of ascorbate on the toxicity of morphine in mice
复制标题
抗坏血酸对小鼠吗啡毒性的影响
DOI：
10.1016/0028-3908(85)90015-2
复制
发表时间：
1985
影响因子：
4.7
通讯作者：
F. Leslie
中科院分区：
文献类型：
--
作者：
C. E. Dunlap;F. Leslie
研究了抗坏血酸对小鼠吗啡毒性的影响。研究发现，在吗啡（500 mg/kg，腹腔注射）前 10 分钟注射腹腔剂量的抗坏血酸钠（1 G/kg）可显着预防呼吸抑制引起的死亡，同时对戊巴比妥的致死率没有影响。抗坏血酸预处理对吗啡在脑组织中的分布没有影响，也没有改变血浆的pH值。体内施用抗坏血酸也不会导致与阿片受体的结合失活。据推测，抗坏血酸通过选择性影响神经元活动来拮抗吗啡的杀伤力。
The effects of ascorbic acid on the toxicity of morphine in mice were investigated. An intraperitoneal dose of sodium ascorbate (1 G/kg) injected 10 min prior to morphine (500 mg/kg, i.p.) was found to provide significant protection against mortality due to respiratory depression, while having no effect on the lethality of the pentobarbital. Pretreatment with ascorbate had no effect on the distribution of morphine in brain tissue, nor did it alter the pH of the plasma. Administration of ascorbatein vivoalso produced no inactivation of binding to opioid receptors. It is postulated that ascorbate antagonizes the lethality of morphine by selectively affecting neuronal activity.