Protective immunity associated with a strong serological response to a Cryptosporidium-specific antigen group, in HIV-infected individuals
Protective immunity associated with a strong serological response to a Cryptosporidium-specific antigen group, in HIV-infected individuals
复制标题
DOI：
10.1086/431681
复制
发表时间：
2005-08-15
影响因子：
6.4
通讯作者：
Kunde, TR
中科院分区：
文献类型：
--
作者：
Frost, FJ;Tollestrup, K;Kunde, TR
本研究评估了隐孢子虫抗原的血清学反应是否与人类免疫缺陷病毒（HIV）感染病例中腹泻疾病的风险降低有关。对隐孢子虫15/17-kDa和27-kDa抗原群的血清学反应与报告的腹泻疾病之间的关系通过使用先前发表的HIV感染病例研究的数据进行了检查。在免疫抑制的个体中，对27-kDa抗原组的强烈血清学反应与腹泻风险降低相关，但体重没有减轻。这一发现表明，获得性保护性免疫对控制免疫抑制个体隐孢子虫病负担可能是重要的。
This study assessed whether serological responses to Cryptosporidium antigens are associated with a reduced risk of diarrheal illness in cases of infection with human immunodeficiency virus (HIV). The association between serological responses to the Cryptosporidium 15/17-kDa and 27-kDa antigen groups and reported diarrheal illness was examined by use of data from a previously published study of cases of HIV infection. In immunosuppressed individuals, a strong serological response to the 27-kDa antigen group was associated with a reduced risk of diarrhea without weight loss. This finding suggests that acquired protective immunity to cryptosporidiosis may be important in controlling the burden of cryptosporidiosis in immunosuppressed individuals.