INVOLVEMENT OF THE SEROTONERGIC SYSTEM IN THE HYPOACTIVE AND ANTINOCICEPTIVE EFFECTS OF NICOTINE IN MICE
INVOLVEMENT OF THE SEROTONERGIC SYSTEM IN THE HYPOACTIVE AND ANTINOCICEPTIVE EFFECTS OF NICOTINE IN MICE
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DOI：
10.1016/0361-9230(94)90252-6
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发表时间：
1994-01-01
影响因子：
3.8
通讯作者：
MARTIN, BR
中科院分区：
文献类型：
--
作者：
DAMAJ, MI;GLENNON, RA;MARTIN, BR
Pretreatment with the 5-HT2 antagonist ketanserin and the 5-HT1A/2 antagonist spiperone did not reduce nicotine-induced hypomotility in mice, nor did MDL 7222, a selective 5-HT3 antagonist. In addition, 8-OH-DPAT and buspirone, 5-HT1A agonists, had no significant effects on nicotine-induced hypomotility. However, 8-OH-DPAT and buspirone did reduce the antinociceptive effects of nicotine in a dose-dependent manner. 8-OH-DPAT blockade af this nicotine effect was reversed by spiperone, a 5-HT1A/2 antagonist. Nicotine's ED(50) was increased from 1.00 mg/kg (0.90-1.68) to 2.00 mg/kg (1.6-2.55) and 2.66 (1.7-3.51) by buspirone and 8-OH-DPAT, respectively. Ketanserin, spiperone and MDL 7222 had no significant effect on nicotine-induced antinociception. The present data suggest an important role of 5-HT1A receptors in the modulation of antinociceptive actions of nicotine.
