Biomimetic Peptide-Gated Nanoporous Membrane for On-Demand Molecule Transport.
Biomimetic Peptide-Gated Nanoporous Membrane for On-Demand Molecule Transport.
复制标题
DOI：
10.1002/anie.201708695
复制
发表时间：
2018-01
影响因子：
--
通讯作者：
Kai Xiao;Kai Wu;Lu Chen;Xiangyu Kong;Yuqi Zhang;L. Wen;Lei Jiang
中科院分区：
文献类型：
--
作者：
Kai Xiao;Kai Wu;Lu Chen;Xiangyu Kong;Yuqi Zhang;L. Wen;Lei Jiang
可控的分子转运对于实现许多在体内和体外的高价值应用是至关重要的。纳米多孔膜具有纳米级孔、高孔隙率、均匀的孔尺寸和可控的表面化学性质，具有实现这一功能的巨大潜力。在此，我们报告了一种基于肽门控纳米多孔膜的按需分子传输纳米门控系统。作为守门人，引入纳米多孔膜的肽提供了通过肽的可逆构象转换实现按需开关状态的机会。这种纳米门控系统提供持续释放，并可用作具有反馈功能的局部药物递送的复杂分子转运平台。
The controllable molecule transport is crucial to realize many highly valuable applications both in vivo and in vitro. Nanoporous membranes, with nanoscopic pores, high porosity, uniform pore dimensions, and controllable surface chemical properties, hold tremendous potential to achieve this function. Herein, we report a nano-gating system for on-demand molecule transport based on a peptide-gated nanoporous membrane. Acting as gatekeeper, the peptides introduced to the nanoporous membrane provide an opportunity to realize on-demand on-off states via reversible conformational switching of the peptides. This nano-gating system offers sustained release and can be used as a sophisticated molecule transport platform for localized drug delivery with a feedback function.