Diagnosis, Treatment and Risk Factors of Strongyloides stercoralis in Schoolchildren in Cambodia
Diagnosis, Treatment and Risk Factors of Strongyloides stercoralis in Schoolchildren in Cambodia
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DOI：
10.1371/journal.pntd.0002035
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发表时间：
2013-02-01
影响因子：
3.8
通讯作者：
Odermatt, Peter
中科院分区：
文献类型：
--
作者：
Khieu, Virak;Schaer, Fabian;Odermatt, Peter
背景：全世界估计有3000万至1亿人感染粪类圆线虫，这是一种土壤传播的蠕虫。在大多数情况下，关于寄生虫的信息很少。在柬埔寨的半农村地区，我们确定了感染率和危险因素，比较了两种诊断方法（古贺琼脂平板[KAP]培养和Baermann技术）检测S。stercoralis感染，使用多种粪便检查的方法，并评估伊维菌素treatment.Methods/主要结果的疗效：我们进行了一项横断面研究，在458名儿童从4所小学在干丹省的半农村村庄，使用三个诊断程序（加藤-卡茨，KAP文化和Baermann技术）的三个粪便样本。感染儿童接受伊维菌素治疗（100 mg/kg/天，持续两天），并在治疗后三周重新检查。Hookworm，S.粪吸虫、鞭虫和小吸虫卵的感染率最高，占24.4%;粪虫KAP培养和Baermann技术的敏感性分别为88.4%和75.0%，阴性预测值分别为96.4%和92.5%。累积患病率S.在分析三个粪便样本后，粪球菌从18.6%增加到24.4%，这接近于模拟的“真实”患病率24.8%。报告在厕所排便的儿童感染S。粪便比那些不使用厕所（p
Background: Worldwide, an estimated 30 to 100 million people are infected with Strongyloides stercoralis, a soil-transmitted helminth. Information on the parasite is scarce in most settings. In semi-rural Cambodia, we determined infection rates and risk factors; compared two diagnostic methods (Koga agar plate [KAP] culture and Baermann technique) for detecting S. stercoralis infections, using a multiple stool examination approach; and assessed efficacy of ivermectin treatment.Methods/Principal Findings: We performed a cross-sectional study in 458 children from four primary schools in semi-rural villages in Kandal province, using three diagnostic procedures (Kato-Katz, KAP culture and Baermann technique) on three stool samples. Infected children were treated with ivermectin (100 mg/kg/day for two days) and re-examined three weeks after treatment. Hookworm, S. stercoralis, Trichuris trichiura, and small trematode eggs were most prevalent, with 24.4% of children being infected with S. stercoralis. The sensitivity of KAP culture and Baermann technique was 88.4% and 75.0%, respectively and their negative predictive values were 96.4% and 92.5%, respectively. The cumulative prevalence of S. stercoralis increased from 18.6% to 24.4%, after analyzing three stool samples, which was close to the modeled 'true' prevalence of 24.8%. Children who reported defecating in latrines were significantly less infected with S. stercoralis than those who did not use latrines (p