EEG slowing and cerebrospinal fluid tau levels in patients with cognitive decline
EEG slowing and cerebrospinal fluid tau levels in patients with cognitive decline
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DOI：
10.1097/00001756-199801050-00032
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发表时间：
1998-01-05
期刊：
影响因子：
1.7
通讯作者：
Wahlund, LO
中科院分区：
文献类型：
--
作者：
Jelic, V;Blomberg, M;Wahlund, LO
我们探讨了脑脊液（CSF）tau水平作为阿尔茨海默病（AD）中tau相关病理学的间接标志物与EEG减慢（该疾病中的典型神经生理学发现）之间的关系。14例AD患者脑脊液tau蛋白水平与α/δ全域功率比值呈正相关（r = 0.65，P = 0.01）。通过二次多项式拟合（p = 0.002）更好地近似该关系。具有较高tau水平和较短病程的AD患者亚组（n = 7）显示CSF tau水平与α/θ（r = 0.83，p = 0.02）和α/δ（r = 0.87，p = 0.01）全局场功率比之间存在强相关性。在12名轻度认知功能障碍患者或14名健康对照受试者中，EEG减慢与CSF tau水平之间无显著相关性。AD患者中tau水平较高且病程较短的患者存在较强的逆线性相关性，这可能意味着随着病程的延长，CSF tau水平由于神经元死亡而降低。
WE explored the relationship between cerebrospinal fluid (CSF) tau levels as indirect markers of tau-related pathology in Alzheimer's disease (AD) and EEG slowing, a typical neurophysiological finding in the disease. A positive correlation between CSF tau levels and ratio of alpha/delta global field power was found in 14 AD patients (r = 0.65, P = 0.01). This relationship was better approximated by polynomial fit of 2nd degree (p, = 0.002). A subgroup of AD patients (n = 7) with higher tau levels and shorter duration of illness showed a strong relationship between CSF tau levels and alpha/theta (r = 0.83, p = 0.02), and alpha/delta (r = 0.87, p = 0.01) ratios of the global field power. There were no significant correlations between EEG slowing and CSF tau levels in 12 patients with mild cognitive dysfunction or in 14 healthy control subjects. That a strong inverse linear correlation exists in AD patients with higher levels of tau and shorter duration of illness may imply that with longer illness duration CSF tau levels decrease due to neuronal death.