Expression and significance of DSCAM in the cerebral cortex of APP transgenic mice
Expression and significance of DSCAM in the cerebral cortex of APP transgenic mice
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DSCAM在APP转基因小鼠大脑皮层中的表达及意义
DOI：
10.1016/j.neulet.2011.01.028
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发表时间：
2011-03-17
影响因子：
2.5
通讯作者：
Jia, Yan-jie
中科院分区：
文献类型：
--
作者：
Jia, Yong-lin;Jing, Li-jun;Jia, Yan-jie
唐氏综合征细胞黏附分子(DSCAM)在突触发生、轴突生长、轴突导向和突触形成等过程中起着重要的调节作用。DSCAM在唐氏综合征(DS)中的过度表达可能通过抑制突触发生/轴突生长而参与智力低下的发病机制，并可能参与与淀粉样前体蛋白(APP)剂量效应相关的早熟痴呆的发病机制，并促进斑块形成。在这份报告中，我们检测了APP转基因小鼠和年龄匹配的野生型小鼠大脑皮层中DSCAM的表达。我们发现，在两组小鼠中，DSCAM的表达水平都随着年龄的增长而增加，在3个月大时达到最大。APP转基因小鼠的DSCAM表达水平显著高于年龄匹配的野生型。我们认为DSCAM在大脑皮层的过度表达可能在APP转基因小鼠学习记忆障碍中起重要作用。(C)2011爱思唯尔爱尔兰有限公司。保留所有权利。
Down syndrome cell adhesion molecule (DSCAM) plays important roles in the regulation of synaptogenesis, neurite outgrowth, axon guidance and synapse formation. Overexpression of DSCAM in Down syndrome (DS) may be involved in the pathogenesis of mental retardation through an inhibitory action on synaptogenesis/neurite outgrowth, and in the precocious dementia associated with an amyloid precursor protein (APP) dosage effect with enhanced plaque formation. In this report we examined the expression of DSCAM in the cerebral cortex of APP transgenic mice versus age-matched wild-type mice. We found that the level of DSCAM expression increased with increasing age in both groups of mice, up to a maximum at 3 months old. The level of DSCAM expression in APP transgenic mice was significantly higher than in the age-matched wild types. We propose that overexpression of DSCAM in the cerebral cortex might play an important role in the learning and memory defects of APP transgenic mice. (C) 2011 Elsevier Ireland Ltd. All rights reserved.