Morning and Evening Blue-Enriched Light Exposure Alters Metabolic Function in Normal Weight Adults.
Morning and Evening Blue-Enriched Light Exposure Alters Metabolic Function in Normal Weight Adults.
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DOI：
10.1371/journal.pone.0155601
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Reid KJ
中科院分区：
文献类型：
--
作者：
Cheung IN;Zee PC;Shalman D;Malkani RG;Kang J;Reid KJ
越来越多的证据表明，明暗暴露模式、摄食行为和新陈代谢之间存在关联。这项研究的目的是确定早晨3小时与晚上3小时蓝光照射与弱光照射相比对饥饿、代谢功能和生理唤醒的急性影响。19名健康成年人在昏暗的光线条件下完成了这项为期4天的住院治疗方案。参与者在第3天被随机分成3个小时的蓝光照射组，从醒后0.5小时(晨组)或醒后10.5小时(晚组)开始(n=10)。所有参与者在第二天仍然处于昏暗的灯光下，作为他们的基线。每小时收集主观饥饿量表和嗜睡量表。血糖、胰岛素、皮质醇、瘦素和胃促生长素的光照时间为4小时，每隔30分钟采集一次血样。计算胰岛素抵抗的稳态模型评估(HOMA-IR)和胰岛素、血糖、HOMA-IR和皮质醇的曲线下面积(AUC)。与基线的比较使用t检验和重复测量方差分析。与弱光相比，早晚两组的胰岛素总面积、HOMA-IR和HOMA-IR AUC均增加，主观嗜睡感减轻。与昏暗的光线相比，夜间组，而不是早晨组，在蓝光照射下的血糖峰值明显更高。早晚两组在对蓝光暴露的反应上没有其他显著差异。蓝光照射可以显著改变葡萄糖代谢和嗜睡，但这种关系背后的机制及其对饥饿和食欲调节的影响仍不清楚。这些结果进一步支持了环境光暴露在新陈代谢调节中的作用。
Increasing evidence points to associations between light-dark exposure patterns, feeding behavior, and metabolism. This study aimed to determine the acute effects of 3 hours of morning versus evening blue-enriched light exposure compared to dim light on hunger, metabolic function, and physiological arousal. Nineteen healthy adults completed this 4-day inpatient protocol under dim light conditions (<20lux). Participants were randomized to 3 hours of blue-enriched light exposure on Day 3 starting either 0.5 hours after wake (n = 9; morning group) or 10.5 hours after wake (n = 10; evening group). All participants remained in dim light on Day 2 to serve as their baseline. Subjective hunger and sleepiness scales were collected hourly. Blood was sampled at 30-minute intervals for 4 hours in association with the light exposure period for glucose, insulin, cortisol, leptin, and ghrelin. Homeostatic model assessment of insulin resistance (HOMA-IR) and area under the curve (AUC) for insulin, glucose, HOMA-IR and cortisol were calculated. Comparisons relative to baseline were done using t-tests and repeated measures ANOVAs. In both the morning and evening groups, insulin total area, HOMA-IR, and HOMA-IR AUC were increased and subjective sleepiness was reduced with blue-enriched light compared to dim light. The evening group, but not the morning group, had significantly higher glucose peak value during blue-enriched light exposure compared to dim light. There were no other significant differences between the morning or the evening groups in response to blue-enriched light exposure. Blue-enriched light exposure acutely alters glucose metabolism and sleepiness, however the mechanisms behind this relationship and its impacts on hunger and appetite regulation remain unclear. These results provide further support for a role of environmental light exposure in the regulation of metabolism.