Semi-autonomous liquid handling via on-chip pneumatic digital logic
Semi-autonomous liquid handling via on-chip pneumatic digital logic
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DOI：
10.1039/c2lc40466d
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发表时间：
2012-01-01
期刊：
影响因子：
6.1
通讯作者：
Hui, Elliot E.
中科院分区：
文献类型：
--
作者：
Nguyen, Transon V.;Duncan, Philip N.;Hui, Elliot E.
本报告提出了一种液体处理芯片，能够执行计量，混合，孵育，并在很大程度上板上气动电路的控制下清洗程序。唯一需要的输入是四条静态选择线，用于在四种机器状态之间进行选择，以及一条额外的电源线。状态选择很简单：持续向输入端施加真空会使设备执行其四个液体处理操作之一。31个阀门的程序控制，包括蠕动泵的快速协调循环，是通过由微流体阀门和通道而不是电子器件构建的气动数字逻辑电路来实现的，从而消除了对集成微流体通常所需的片外控制机械的需要。
This report presents a liquid-handling chip capable of executing metering, mixing, incubation, and wash procedures largely under the control of on-board pneumatic circuitry. The only required inputs are four static selection lines to choose between the four machine states, and one additional line for power. State selection is simple: constant application of vacuum to an input causes the device to execute one of its four liquid handling operations. Programmed control of 31 valves, including fast coordinated cycling for peristaltic pumping, is accomplished by pneumatic digital logic circuits built out of microfluidic valves and channels rather than electronics, eliminating the need for the off-chip control machinery that is typically required for integrated microfluidics.