NATURAL-HISTORY OF INTRAHEPATIC CANINE ISLET CELL AUTOGRAFTS
NATURAL-HISTORY OF INTRAHEPATIC CANINE ISLET CELL AUTOGRAFTS
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DOI：
10.1172/jci112720
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发表时间：
1986-11-01
影响因子：
15.9
通讯作者：
MINTZ, DH
中科院分区：
文献类型：
--
作者：
ALEJANDRO, R;CUTFIELD, RG;MINTZ, DH
我们连续跟踪了15只比格犬肝内自体胰岛移植物的功能，长达24个月。在这些患者中，只有20%的患者在移植后15个月内维持正常的空腹血糖水平。自体移植物功能的失败伴随着移植胰岛中颗粒化良好的β细胞的优先损失。最初边缘肝内β细胞团的慢性刺激最终导致代谢恶化和β细胞损失低于维持正常空腹血糖水平所需的最低阈值。在犬中移植大量胰岛可能导致移植物功能不确定。然而，在包括人类在内的大型哺乳动物中，最初在异位部位（如肝脏）中足够的胰岛细胞团是否可以在长时间内保持功能活性仍有待证明。
We have serially followed the function of intrahepatic canine islet autografts in 15 beagle dogs for up to 24 mo. Of these, only 20% sustained normal levels of fasting blood glucose for > 15 mo posttransplant. Failure of autograft function was accompanied by a preferential loss of well-granulated beta cells in the engrafted islets. The chronic stimulation of an initially marginal intrahepatic beta-cell mass ultimately resulted in metabolic deterioration and loss of beta cells below the minimal threshold required to maintain normal fasting blood glucose levels. It is possible that transplantation of a larger mass of islets would result in indefinite graft function in dogs. However, it remains to be demonstrated in larger mammals, including humans, whether an islet cell mass that is initially adequate in a heterotopic site such as the liver can remain functionally competent over a prolonged period.