CARDIOVASCULAR REGULATION IN TGR(mREN2)27 RATS: 24h VARIATION IN PLASMA CATECHOLAMINES, ANGIOTENSIN PEPTIDES, AND TELEMETRIC HEART RATE VARIABILITY
CARDIOVASCULAR REGULATION IN TGR(mREN2)27 RATS: 24h VARIATION IN PLASMA CATECHOLAMINES, ANGIOTENSIN PEPTIDES, AND TELEMETRIC HEART RATE VARIABILITY
复制标题
TGR(mREN2)27 大鼠的心血管调节：血浆儿茶酚胺、血管紧张素肽和遥测心率变异性的 24 小时变化
DOI：
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发表时间：
2001
影响因子：
2.8
通讯作者：
B. Lemmer
中科院分区：
文献类型：
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作者：
S. Schiffer;S. Pummer;K. Witte;B. Lemmer
交感神经系统功能障碍可能在转基因高血压TGR(MREN2)27(TGR)大鼠24小时血压调节紊乱中起重要作用。为探讨TGR大鼠交感神经系统活动与正常血压的SD大鼠(SPRD)的差异，我们在同步光暗12h：12h(LD 12：12)条件下，测定了TGR大鼠血浆儿茶酚胺和血管紧张素水平。在TGR大鼠品系中，血浆儿茶酚胺的节律被钝化，浓度显著降低。此外，TGR大鼠血浆血管紧张素I和血管紧张素II浓度升高，但没有任何明显的节律。通过监测TGR大鼠的心率变异性，证实了自主神经调节受损。数据显示，TGR大鼠品系的特征是血浆儿茶酚胺减少，血管紧张素肽增加。目前，尚不清楚儿茶酚胺的减少是由压力感受性反射激活引起的交感神经张力降低，还是由血管紧张素II升高引起的儿茶酚胺周转增加。然而，TGR大鼠血浆儿茶酚胺的钝化但正常的阶段性节律使交感神经系统不太可能是转基因品系血压昼夜节律逆转的主要原因。(《国际时间生物学》，18(3)，461-474,2001)
Dysfunction of the sympathetic nervous system might play an important role in disturbed 24h blood pressure regulation in transgenic hypertensive TGR (mREN2)27 (TGR) rats. Our study was performed to determine possible differences in activity of the sympathetic nervous system in TGR rats in comparison to their normotensive Sprague-Dawley (SPRD) controls; we measured plasma catecholamine and angiotensin concentrations throughout 24h under synchronized light-dark 12h:12H (LD 12:12) conditions. In the TGR rat strain, rhythms of plasma catecholamines were blunted, and the concentrations were significantly decreased. In addition, TGR rats showed increased plasma angiotensin I and II concentrations without any significant rhythm. An impaired autonomic regulation was confirmed by monitoring heart rate variability in TGR rats. Data showed that the TGR rat strain is characterized by a reduction in plasma catecholamines and an increase in angiotensin peptides. At present, it is not clear whether the reduction in catecholamines represents a decrease in sympathetic tone mediated by baroreflex activation or an increased catecholamine turnover induced by elevated angio-tensin II. However, the blunted, but normally phased, rhythms in plasma catecholamines in TGR rats make it unlikely that the sympathetic nervous system is mainly responsible for the inverse circadian blood pressure rhythm in the transgenic strain. (Chronobiology International, 18(3), 461–474, 2001)