Structural and functional alterations of gut microbiome in mice induced by chronic cadmium exposure
Structural and functional alterations of gut microbiome in mice induced by chronic cadmium exposure
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DOI：
10.1016/j.chemosphere.2019.125747
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发表时间：
2020-05-01
期刊：
影响因子：
8.8
通讯作者：
Zhang, Xu-Xiang
中科院分区：
文献类型：
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作者：
He, Xiwei;Qi, Zhaodong;Zhang, Xu-Xiang
哺乳动物肠道微生物群容易受到急性或亚慢性镉（Cd）中毒的影响，但其在环境相关水平慢性镉暴露后的易感性尚不清楚。本研究全面评估了饮用水中10和50 ppm剂量的镉暴露20周对小鼠肠道微生物群的影响。结果表明，Cd暴露诱导肠道形态学改变，并可能增加肠道通透性和炎症。这些变化伴随着肠道微生物群的明显扰动，其特征是肠道微生物丰富度显著降低，产生短链脂肪酸（SCFA）的细菌丰度降低，导致肠道中SCFA的产生减少。此外，Cd暴露引起了肠道微生物群代谢功能的实质性变化，对氨基酸、碳水化合物和能量代谢相关的基因通路有明显的抑制作用，对谷胱甘肽代谢和氨基苯甲酸酯降解等代谢通路有促进作用。我们的研究结果为环境镉暴露对肠道微生物群的危害评估提供了新的见解。(C) 2019 Elsevier Ltd.版权所有。
Mammalian gut microbiome is readily affected by acute or subchronic cadmium (Cd) intoxication, but it susceptibility following chronic Cd exposure at environmentally-relevant levels remains unknown. This study comprehensively assessed the effects of Cd exposure at doses of 10 and 50 ppm in drinking water for 20 weeks on gut microbiome in mice. Results showed that the Cd exposure induced alterations in gut morphology with potentially increased gut permeability and inflammation. These changes were accompanied by marked perturbation of gut microbiota characterized by significantly decreased gut microbial richness and lowered abundance of short chain fatty acid (SCFA)-producing bacteria, resulting in reduced SCFAs production in the gut. Moreover, the Cd exposure caused substantial metabolic functional changes of the gut microbiome, with significant inhibitions on gene pathways associated with metabolism of amino acid, carbohydrate, and energy, as well as promotions on metabolic pathways such as glutathione metabolism and aminobenzoate degradation. Our findings provide new insights into the hazards assessment of environmental Cd exposure towards gut microbiome. (C) 2019 Elsevier Ltd. All rights reserved.