Alzheimer's disease: the lipid connection
Alzheimer's disease: the lipid connection
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DOI：
10.1111/j.1471-4159.2007.04715.x
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发表时间：
2007-11-01
影响因子：
4.7
通讯作者：
Grimm, Marcus O. W.
中科院分区：
文献类型：
--
作者：
Hartmann, Tobias;Kuchenbecker, Johannna;Grimm, Marcus O. W.
阿尔茨海默病是最常见的神经退行性疾病。这篇简短的综述总结了目前关于脂质，特别是胆固醇，鞘脂，缩醛磷脂和多不饱和脂肪酸在阿尔茨海默病病因，发病机制，危险因素，预防，治疗中的作用的知识，以及淀粉样前体蛋白和淀粉样肽在脂质稳态中的功能。
Alzheimer's disease is the most common neurodegenerative disorder. This short review summarizes the current knowledge about the role of lipids, especially cholesterol, sphingolipids, plasmalogens, and polyunsaturated fatty acids in Alzheimer's disease etiology, pathogenesis, risk-factors, prevention, treatment, and the function of the amyloid precursor protein and the amyloid peptides in lipid homeostasis.