ISOLATION AND CHARACTERIZATION OF A CDNA CLONE FOR THE MURINE-I-E-BETA POLYPEPTIDE-CHAIN
ISOLATION AND CHARACTERIZATION OF A CDNA CLONE FOR THE MURINE-I-E-BETA POLYPEPTIDE-CHAIN
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DOI：
10.1073/pnas.80.24.7621
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发表时间：
1983-01-01
期刊：
影响因子：
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通讯作者：
MCDEVITT, HO
中科院分区：
文献类型：
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作者：
MENGLEGAW, L;MCDEVITT, HO
Ia 抗原在主要组织相容性复合物的 I 区域内编码，是一组参与免疫反应控制的细胞表面糖蛋白。 1 个鼠类免疫反应基因的 1045 个碱基对 c[互补]DNA 克隆的序列，.**图形**。已确定。 **GRAPHIC** 产物的预测氨基酸序列比较。与.**图形**的。显示大多数氨基酸差异聚集在第一个外部蛋白质结构域中的短肽序列中。等位基因变异的这种聚集表明，观察到的对某些抗原的单倍型特异性免疫反应可能至少部分地受到由E.beta的NH2末端结构域中等位基因变异性的这些区域所定义的构型差异的控制。链。
The Ia antigens, encoded within the I region of the major histocompatibility complex, are a group of cell surface glycoproteins that are involved in the control of immune responsiveness. The sequence of a 1045-base-pair c[complementary]DNA clone for 1 of the murine immune response genes, .**GRAPHIC**. was determined. Comparison of the predicted amino acid sequence of the product of .**GRAPHIC**. with that of .**GRAPHIC**. shows that most of the amino acid differences are clustered in short stretches of peptide sequence in the 1st external protein domain. This clustering of allelic variation suggests that observed haplotype-specific immune responsiveness to certain antigens may be controlled, at least in part, by differences in configuration defined by these regions of allelic variability in the NH2-terminal domain of the E.beta. chain.