Caveolae, caveolins, cavins, and endothelial cell function: new insights.
Caveolae, caveolins, cavins, and endothelial cell function: new insights.
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DOI：
10.3389/fphys.2011.00120
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发表时间：
2012
影响因子：
4
通讯作者：
Sowa G
中科院分区：
文献类型：
--
作者：
Sowa G
小窝是质膜上富含胆固醇和鞘糖脂的瓶状内陷，在血管内皮细胞中特别丰富，在心血管系统的所有其他类型的细胞中都存在，包括血管平滑肌细胞、巨噬细胞、心肌细胞和成纤维细胞。小窝蛋白和最近发现的小窝蛋白是小窝的主要蛋白质成分。当小窝被发现时，它们的功能被认为仅限于运输穿过内皮细胞屏障。然而，从那时起，大量的证据表明，这些微域在调节许多其他重要的内皮细胞功能方面非常重要，主要是由于它们能够集中和分隔各种信号分子。在几年的时间里，涉及敲除小鼠和小干扰RNA方法的多项研究极大地提高了我们对小窝和小窝-1在调节许多心血管功能中的作用的理解。据报道，新的发现涉及内皮细胞信号和功能中的其他空泡蛋白成分，例如未被研究的小窝蛋白-2和新发现的空泡蛋白。这篇综述的目的主要集中在小窝、小窝蛋白和小窝蛋白在内皮细胞信号和功能中的作用的分子和细胞方面。此外，在适当的情况下，可能对心血管和肺生理学以及病理生理学的影响也将被讨论。
Caveolae are cholesterol and glycosphingolipid-rich flask-shaped invaginations of the plasma membrane which are particularly abundant in vascular endothelium and present in all other cell types of the cardiovascular system, including vascular smooth-muscle cells, macrophages, cardiac myocytes, and fibroblasts. Caveolins and the more recently discovered cavins are the major protein components of caveolae. When caveolae were discovered, their functional role was believed to be limited to transport across the endothelial cell barrier. Since then, however, a large body of evidence has accumulated, suggesting that these microdomains are very important in regulating many other important endothelial cell functions, mostly due to their ability to concentrate and compartmentalize various signaling molecules. Over the course of several years, multiple studies involving knockout mouse and small interfering RNA approaches have considerably enhanced our understanding of the role of caveolae and caveolin-1 in regulating many cardiovascular functions. New findings have been reported implicating other caveolar protein components in endothelial cell signaling and function, such as the understudied caveolin-2 and newly discovered cavin proteins. The aim of this review is to focus primarily on molecular and cellular aspects of the role of caveolae, caveolins, and cavins in endothelial cell signaling and function. In addition, where appropriate, the possible implications for the cardiovascular and pulmonary physiology and pathophysiology will be discussed.
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DOI：
10.1152/ajpregu.00092.2007
发表时间：
2007-09-01
影响因子：
2.8
作者：
Albinsson, Sebastian;Shakirova, Yulia;Swaerd, Karl
通讯作者：
Swaerd, Karl
影响因子：
29
作者：
Fernández-Hernando C;Yu J;Suárez Y;Rahner C;Dávalos A;Lasunción MA;Sessa WC
通讯作者：
Sessa WC
DOI：
10.1083/jcb.200903053
发表时间：
2009-06-29
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bastiani M;Liu L;Hill MM;Jedrychowski MP;Nixon SJ;Lo HP;Abankwa D;Luetterforst R;Fernandez-Rojo M;Breen MR;Gygi SP;Vinten J;Walser PJ;North KN;Hancock JF;Pilch PF;Parton RG
通讯作者：
Parton RG
影响因子：
82.9
作者：
Bucci, M;Gratton, JP;Sessa, WC
通讯作者：
Sessa, WC
影响因子：
10.8
作者：
Dubroca, Caroline;Loyer, Xavier;Henrion, Daniel
通讯作者：
Henrion, Daniel