Supplemental nicotine preloading for smoking cessation in posttraumatic stress disorder: Results from a randomized controlled trial
Supplemental nicotine preloading for smoking cessation in posttraumatic stress disorder: Results from a randomized controlled trial
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DOI：
10.1016/j.addbeh.2016.03.004
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发表时间：
2016-08-01
影响因子：
4.4
通讯作者：
Calhoun, Patrick S.
中科院分区：
文献类型：
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作者：
Dennis, Paul A.;Kimbrel, Nathan A.;Calhoun, Patrick S.
背景：患有创伤后应激障碍（PTSD）的个体比没有创伤后应激障碍的个体更容易吸烟，更容易在戒烟后复发。因此，有必要研究有希望的干预措施，以提高PTSD吸烟者的戒烟率。其中一种干预措施是补充尼古丁贴片预负荷，需要在戒烟前使用尼古丁替代疗法。目的本研究的目的是进行一项随机对照试验，研究补充尼古丁贴片预负荷对PTSD吸烟者的疗效。我们假设，相对于安慰剂组的参与者，尼古丁贴片预加载组的参与者会：(1)在尼古丁贴片预加载阶段吸烟减少，对香烟的渴望减少；(2)在预负荷阶段，与吸烟相关的PTSD症状和负性情绪缓解较少；(3)表现出更大的潜伏期，以及更高的短期和长期戒断率。方法：63名患有PTSD的吸烟者在戒烟前三周随机服用尼古丁贴片或安慰剂贴片。生态瞬时评估用于评估预负荷期间的渴望、吸烟、创伤后应激障碍症状和负面情绪。结果：尼古丁贴片预加载在预加载阶段不能减少吸烟或渴望，也不能减少与吸烟相关的PTSD症状和负面影响的缓解。此外，在时间流逝、6周戒断和6个月戒断的治疗条件之间没有观察到差异。结论：目前的研究结果表明，补充尼古丁贴片预负荷不太可能显著提高PTSD吸烟者的戒烟率。Elsevier Ltd.出版。
Background: Individuals with posttraumatic stress disorder (PTSD) are more likely to smoke and more likely to relapse following a quit attempt than individuals without PTSD. Thus, there is a significant need to study promising interventions that might improve quit rates for smokers with PTSD. One such intervention, supplemental nicotine patch-preloading, entails the use of nicotine replacement therapy prior to quitting.ObjectiveThe objective of this study was to conduct a randomized controlled trial of the efficacy of supplemental nicotine patch-preloading among smokers with PTSD. We hypothesized that, relative to participants in the placebo condition, participants in the nicotine patch-preloading condition would: (1) smoke less and experience reduced craving for cigarettes during the nicotine patch-preloading phase; (2) experience less smoking-associated relief from PTSD symptoms and negative affect during the preloading phase; and (3) exhibit greater latency to lapse, and higher short- and long-term abstinence rates.Methods: Sixty-three smokers with PTSD were randomized to either nicotine or placebo patch for three weeks prior to their quit date. Ecological momentary assessment was used to assess craving, smoking, PTSD symptoms, and negative affect during the preloading period.Results: Nicotine patch-preloading failed to reduce smoking or craving during the preloading phase, nor was it associated with less smoking-associated relief from PTSD symptoms and negative affect. Moreover, no differences were observed between the treatment conditions for time to lapse, 6-week abstinence, or 6-month abstinence.Conclusions: The findings from the present research suggest that supplemental nicotine patch-preloading is unlikely to substantially enhance quit rates among smokers with PTSD. Published by Elsevier Ltd.