Effect of Taurine on the Regulation of Glucose Uptake in the Skeletal Muscle
Effect of Taurine on the Regulation of Glucose Uptake in the Skeletal Muscle
复制标题
牛磺酸对骨骼肌葡萄糖摄取调节的影响
DOI：
10.1007/978-3-030-93337-1_29
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发表时间：
2022
影响因子：
--
通讯作者：
Ra Song-Gyu
中科院分区：
文献类型：
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作者：
鈴木 英樹 ;辻本 尚弥 ;北浦 孝;Akiyoshi Matsugi;笠原政志;Ra Song-Gyu
糖尿病在日本非常普遍，被称为国病。牛磺酸是一种在哺乳动物组织中大量存在的游离氨基酸，也是许多“能量饮料”的关键成分，已被证明对改善由糖尿病引起的高血糖状态有效。牛磺酸给药与胰腺胰岛素分泌增加、胰岛素信号相关因子水平升高和葡萄糖转运蛋白GLUT4表达升高有关。骨骼肌是胰岛素的主要靶器官：肌细胞通过细胞表面GLUT4分子摄取血糖，使骨骼肌收缩。牛磺酸对骨骼肌血糖摄取的促进作用尚未得到充分的研究，其机制也知之甚少。本文综述了牛磺酸对胰腺胰岛素分泌的影响，特别是对骨骼肌血糖摄取的影响。
Diabetes is so common in Japan as to be called a national disease. Taurine, a free amino acid found abundantly in mammalian tissues that is also a key ingredient of many “energy drinks,” has been shown to be effective in improving the hyperglycemic state caused by diabetes. Taurine administration is associated with increased insulin secretion from the pancreas, higher levels of insulin signaling-related factors, and higher expression of the glucose transporter, GLUT4. Skeletal muscle is the main target organ of insulin: Via cell surface GLUT4 molecules, myocytes take up blood glucose, enabling skeletal muscle contraction. The enhancing effect of taurine on blood glucose uptake in skeletal muscle has not been fully studied, and little is known about its mechanism. This review article summarizes what is known about the effects of taurine on insulin secretion from the pancreas and especially blood glucose uptake in skeletal muscle.