A prospective study of the intake of vitamins C and B6, and the risk of kidney stones in men
A prospective study of the intake of vitamins C and B6, and the risk of kidney stones in men
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DOI：
10.1016/s0022-5347(01)66027-0
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发表时间：
1996-06-01
影响因子：
6.6
通讯作者：
Stampfer, MJ
中科院分区：
文献类型：
--
作者：
Curhan, GC;Willett, WC;Stampfer, MJ
目的：研究维生素C和维生素B6的摄入与肾结石形成之间的关系。材料和方法：我们对45251名40 - 75岁无肾结石病史的男性进行了一项前瞻性研究，研究维生素C和B6的摄入与症状性肾结石风险之间的关系。通过1986年完成的半定量食物频率问卷来评估从食物和补充剂中摄入的维生素。结果：在6年的随访中，记录了751例肾结石病例。维生素C和维生素B6的摄入与结石形成的风险都没有显著关联。对于维生素C，每天摄入1500毫克或更多的男性与每天摄入少于250毫克的男性相比，年龄调整后的相对风险为0.78（95%可信区间为0.54至1.11）。对于维生素B6，每天摄入40毫克或更多的男性与每天摄入少于3毫克的男性相比，年龄调整后的相对风险为0.91（95%可信区间为0.64至1.31）。在调整了其他潜在的结石危险因素后，相对风险没有显著变化。结论：这些数据不支持每日大量摄入维生素C或维生素B6与结石形成风险之间的联系，即使是大剂量摄入。
Purpose: The association between the intake of vitamins C and B6, and kidney stone formation was examined.Materials and Methods: We conducted a prospective study of the relationship between the intake of vitamins C and B6 and the risk of symptomatic kidney stones in a cohort of 45,251 men 40 to 75 years old with no history of kidney calculi. Vitamin intake from foods and supplements was assessed using a semiquantitative food frequency questionnaire completed in 1986.Results: During 6 years of followup 751 incident cases of kidney stones were documented. Neither vitamin C nor vitamin B6 intake was significantly associated with the risk of stone formation. For vitamin C the age-adjusted relative risk for men consuming 1,500 mg. daily or more compared to less than 250 mg. daily was 0.78 (95% confidence interval 0.54 to 1.11). For vitamin B6 the age-adjusted relative risk for men consuming 40 mg. daily or more compared to less than 3 mg. daily was 0.91 (95% confidence interval 0.64 to 1.31). After adjusting for other potential stone risk factors the relative risks did not change significantly.Conclusions: These data do not support an association between a high daily intake of vitamin C or vitamin B6 and the risk of stone formation, even when consumed in large doses.