Clarifying the role of (apical) K+ channels in Na+ and Cl- transport.
Clarifying the role of (apical) K+ channels in Na+ and Cl- transport.
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阐明（顶端）K 通道在 Na 和 Cl 运输中的作用。
DOI：
10.1113/jphysiol.2011.213116
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Schultz,Bruce
中科院分区：
文献类型：
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作者：
Schultz,Bruce
一位同事曾经说过：“天堂是一个你可以一次只处理一个问题的地方。他的发言反映了这样一个事实，即在一个复杂的系统中，如果不同时界定其他互补、竞争或支持性组成部分的活动，就无法界定甚至调查一个组成部分的作用。这种“非天堂状态”是人们定义上皮离子转运的情况。在最近一期的《生理学杂志》上，Palmer及其同事（Palmer et al. 2011）澄清了一个特定的K+通道KCa 3的贡献。1、使上皮细胞向净离子转运。结果是有趣的，因为它解决了K+分泌和Na+吸收在一个特定的上皮细胞系统，人类乳腺。在这项工作和以前的工作（李等人，2007年），作者报告说，KCa3。1，KCNN4基因的产物，在乳腺上皮细胞的顶端和基底侧膜中表达，重要的是，它似乎在这两个位置独立调节。
A colleague once stated that ‘Heaven is a place where you can deal with just one issue at a time.’His statement reflected the fact that, in a complex system, one cannot define or even investigate the role of one component without simultaneously defining the activities of other complimentary, competing, or supporting components. This ‘un-heavenly state’is the situation as one defines epithelial ion transport. It is impossible to study one ion transport mechanism without defining the rest of the system and changes in one mechanism reverberate to affect all other components.In a recent issue of The Journal of Physiology, Palmer and colleagues (Palmer et al. 2011) add clarity to the contribution that a particular K+ channel, KCa3. 1, makes to net epithelial ion transport. The outcome is intriguing because it addresses both K+ secretion and Na+ absorption in a particular epithelial cell system, the human mammary gland. In this and previous work (Lee et al. 2007) the authors report that KCa3. 1, the product of the KCNN4 gene, is expressed in both the apical and basolateral membrane of mammary epithelial cells and, importantly, that it appears to be regulated independently at the two locations.