veqtl-mapper: variance association mapping for molecular phenotypes.
veqtl-mapper: variance association mapping for molecular phenotypes.
复制标题
veqtl-mapper：分子表型的方差关联映射。
DOI：
10.1093/bioinformatics/btx273
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Brown,AndrewAnand
中科院分区：
文献类型：
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作者：
Brown,AndrewAnand
与表型性状变异相关的遗传基因座最近引起了人们的兴趣，因为它们可以是遗传互作、基因与环境互作、起源亲本效应和管道化的标志。我们提出了一种快速有效的工具来定位影响顺式基因表达变异和其他分子表型的基因座。结果：在公开可用的Geuvadis基因表达数据集上，我们使用加性模型识别了816个与基因表达差异相关的基因座，其中32个显示了纯合子和杂合等位基因之间的差异，来源效应的亲本签名。可用性和实现可在https://funpopgen.github.io/veqm/.Supplementary信息中找到文档和指向LINUX源代码和二进制文件的链接。补充数据可在BioInformation Online上找到。
MotivationGenetic loci associated with the variance of phenotypic traits have been of recent interest as they can be signatures of genetic interactions, gene by environment interactions, parent of origin effects and canalization. We present a fast efficient tool to map loci affecting variance of gene expression and other molecular phenotypes in cis. Results: Applied to the publicly available Geuvadis gene expression dataset, we identify 816 loci associated with variance of gene expression using an additive model, and 32 showing differences in variance between homozygous and heterozygous alleles, signatures of parent of origin effects.Availability and implementationDocumentation and links to source code and binaries for linux can be found at https://funpopgen.github.io/veqm/.Supplementary informationSupplementary data are available atBioinformaticsonline.