Relationship between the susceptibility of various bacteria to active oxygen species and to intracellular killing by macrophages.
Relationship between the susceptibility of various bacteria to active oxygen species and to intracellular killing by macrophages.
复制标题
各种细菌对活性氧的敏感性与巨噬细胞细胞内杀伤之间的关系。
DOI：
10.1099/00221287-133-8-2015
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
J. Jidoi
中科院分区：
文献类型：
--
作者：
Y. Yamada;H. Saito;H. Tomioka;J. Jidoi
六种微生物对黄嘌呤氧化酶介导的杀菌系统中产生的活性氧的亲和性如下：大肠杆菌81大于或等于单核细胞增生李斯特菌EGD大于或等于鼠伤寒沙门氏菌HKB-1大于或等于金黄色葡萄球菌Smith远大于结核分枝杆菌H37 Rv大约等于白色念珠菌NIH A207（最后两种微生物基本上对该系统具有抗性）。H_2O_2-Fe介导的卤化体系具有较高的杀菌活性。当比较微生物对小鼠腹腔巨噬细胞（M phi s）杀菌活性的敏感性时，C。白色念珠菌、葡萄球菌aureus和E.大肠杆菌迅速死亡，而M. tuberculosis，L.单核细胞增多症和S.鼠伤寒沙门氏菌的耐药性更强。在小鼠腹膜M phi s中触发氧化爆发的能力测试中（通过化学发光测量），葡萄球菌。金黄色葡萄球菌表现出最高的活性，其次是其他生物体，顺序如下：C. albicans大于E. coli大于L.单核细胞增多症与M.结核S.鼠伤寒沙门氏菌没有表现出触发活性。葡萄球菌的高敏感性。aureus和E.大肠杆菌对M phi杀菌活性的耐药性，以及L.单核细胞增多症和M.结核病，与他们的敏感性，活性氧和H2 O2-Fe介导的卤化反应。
The susceptibilities of six micro-organisms to active oxygen species generated in the xanthine oxidase-mediated bactericidal system were as follows: Escherichia coli 81 greater than or equal to Listeria monocytogenes EGD greater than or equal to Salmonella typhimurium HKB-1 greater than or equal to Staphylococcus aureus Smith much greater than Mycobacterium tuberculosis H37Rv approximately equal to Candida albicans NIH A207 (the last two organisms were essentially resistant to this system). The H2O2-Fe-mediated halogenation system exhibited a higher microbicidal activity. When the micro-organisms were compared for their sensitivity to bactericidal activity of resident mouse peritoneal macrophages (M phi s), C. albicans, Staph. aureus and E. coli were killed rapidly, whereas M. tuberculosis, L. monocytogenes and S. typhimurium were more resistant. In tests for the ability to trigger an oxidative burst in mouse peritoneal M phi s (as measured by chemiluminescence), Staph. aureus showed the highest activity followed by the other organisms in the following order: C. albicans greater than E. coli greater than L. monocytogenes congruent to M. tuberculosis. S. typhimurium exhibited no triggering activity. The high susceptibility of Staph. aureus and E. coli to M phi bactericidal activity, and the partial resistance of L. monocytogenes and M. tuberculosis, correlated with their susceptibility to active oxygen and the H2O2-Fe-mediated halogenation reaction.
黄嘌呤氧化酶系统催化的碘化：羟基自由基的作用。
影响因子：
2.9
作者：
Klebanoff,SJ
通讯作者：
Klebanoff,SJ