Gut hormone release and appetite regulation in healthy non-obese participants following oligofructose intake. A dose-escalation study
Gut hormone release and appetite regulation in healthy non-obese participants following oligofructose intake. A dose-escalation study
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DOI：
10.1016/j.appet.2013.02.017
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发表时间：
2013-07-01
期刊：
影响因子：
5.4
通讯作者：
Frost, Gary S.
中科院分区：
文献类型：
--
作者：
Pedersen, Camilla;Lefevre, Solenne;Frost, Gary S.
预防成人体重增加是一项主要的公共卫生目标。动物实验一致证明了可发酵碳水化合物的摄入（如低聚果糖）、肠道厌食激素与食欲抑制和体重控制之间的关系。本研究旨在确定低聚果糖的剂量，以增加非肥胖者肠道厌食激素的释放并持续降低食欲。12名非肥胖参与者被招募进行为期5周的剂量递增研究。经过9-14天的磨合，参与者每周的低聚果糖摄入量从15、25、35、45克增加到55克。每天监测主观食欲和副作用。每周完成三天的饮食日记。食欲研究探讨了0、15、35和55 g低聚果糖对食欲相关激素、血糖、主观食欲和能量摄入的急性影响。在家庭环境中，低聚果糖抑制饥饿感，但不影响能量摄入。低聚果糖剂量依赖性地增加YY肽，降低胰多肽，并倾向于降低胃饥饿素，但在食欲研究期间对食欲特征、能量摄入、葡萄糖、胰岛素或胰高血糖素样肽1浓度没有显著影响。综上所述，饲粮中添加低聚果糖（>= 35 g/d）可增加YY肽，抑制胰多肽和饥饿感；然而，能量摄入没有显著变化。(C) 2013 Elsevier Ltd.版权所有。
Prevention of weight gain in adults is a major public health target. Animal experiments have consistently demonstrated a relationship between fermentable carbohydrate intake, such as oligofructose, anorectic gut hormones, and appetite suppression and body weight control. This study was designed to determine the dose of oligofructose which would augment the release of anorectic gut hormones and reduce appetite consistently in non-obese humans. Twelve non-obese participants were recruited for a 5-week dose-escalation study. Following a 9-14-day run-in, participants increased their daily oligofructose intake every week from 15, 25, 35, 45, to 55 g daily. Subjective appetite and side effects were monitored daily. Three-day food diaries were completed every week. Appetite study sessions explored the acute effects of 0, 15, 35, and 55 g oligofructose on appetite-related hormones, glycaemia, subjective appetite, and energy intake. In the home environment, oligofructose suppressed hunger, but did not affect energy intake. Oligofructose dose-dependently increased peptide YY, decreased pancreatic polypeptide and tended to decrease ghrelin, but did not significantly affect appetite profile, energy intake, glucose, insulin, or glucagon-like peptide 1 concentrations during appetite study sessions. In conclusion, oligofructose supplementation at >= 35 g/day increased peptide YY and suppressed pancreatic polypeptide and hunger; however, energy intake did not change significantly. (C) 2013 Elsevier Ltd. All rights reserved.