The occurrence of respiratory events in young subjects with a frequent rhythmic masticatory muscle activity: a pilot study
The occurrence of respiratory events in young subjects with a frequent rhythmic masticatory muscle activity: a pilot study
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DOI：
10.1016/j.jpor.2017.12.004
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发表时间：
2018-07-01
影响因子：
3.6
通讯作者：
Kato, Takafumi
中科院分区：
文献类型：
--
作者：
Tsujisaka, Akiko;Haraki, Shingo;Kato, Takafumi
目的：伴随呼吸事件的发生在SB的临床实践中常常被忽视。本研究评价了无症状阻塞性睡眠呼吸暂停(OSA)的青少年磨牙症(SB)患者的节律性咀嚼肌活动(RMMA)和伴随的呼吸事件的生理特征。方法：22例受试者(年龄24.1±1.9岁；女性8例，男性14例；BMI：20.2±1.9 kg/m(2))经多导睡眠图诊断为中重度SB。记录睡眠结构、口运动(RMMA和非特异性咬肌活动[NSMA])和呼吸暂停/低呼吸事件。结果：所有受试者睡眠结构正常，6例轻度阻塞性睡眠呼吸暂停综合征患者出现呼吸事件。在所有受试者中，RMMA主要发生在N1+N2期，而NSMA发生在N1+N2期(约60%)和R期(高达30%)。高达50%的呼吸事件发生在R期，RMMA在6例阻塞性睡眠呼吸暂停患者中与呼吸事件密切相关(例如，在10 S以内)比非阻塞性睡眠呼吸暂停患者更频繁。与呼吸事件密切相关的RMMA仅与N1+N2期的呼吸暂停低通气指数(AHI)呈正相关，而NSMA与N1+N2期和R期的AHI呈正相关。需要进一步的大样本研究来证明亚临床呼吸事件的发生代表了SB的一种临床亚型。(C)2017年日本口腔修复学会。爱思唯尔有限公司出版。保留所有权利。
Purpose: Concomitant occurrence of respiratory events can be often overlooked in the clinical practice of SB. This study assessed physiological characteristics of rhythmic masticatory muscle activity (RMMA) and concomitant respiratory events in young sleep bruxism (SB) subjects asymptomatic to obstructive sleep apnea (OSA).Methods: Twenty-two subjects (age: 24.1 +/- 1.9 years; F 8: M 14; BMI: 20.2 +/- 1.9 kg/m(2)) were polysomnographically diagnosed as moderate-severe SB. Sleep architecture, oromotor (RMMA and nonspecific masseter activity [NSMA]) and apnea/hypopnea events were scored.Results: All subjects showed normal sleep architecture whereas 6 exhibited respiratory events at a mild level of OSA. In all subjects, RMMA predominantly occurred in Stage N1 + N2 while NSMA occurred in Stage N1 + N2 (approximately 60 %) and in Stage R (up to 30 %). Up to 50 % of respiratory events were scored in Stage R. RMMA occurred more frequently in close association (e.g., within 10 s) with respiratory events in 6 subjects with OSA than those without. The percentage of RMMA occurring closely to respiratory events was positively correlated with apnea-hypopnea index (AHI) in Stage N1 + N2 only while that of NSMA was positively correlated with AHI in Stage N1 + N2 and Stage R. A sub-analysis in 6 subjects with OSA, RMMA after respiratory events was followed to arousals while those before respiratory events were mostly associated with central apnea.Conclusions: A subpopulation of young SB subjects can show concomitant respiratory events. Further large sample studies are needed to demonstrate that the occurrence of subclinical respiratory events represents a clinical subtype of SB. (C) 2017 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved.