New pertussis vaccination strategies beyond infancy:: Recommendations by the global pertussis initiative
New pertussis vaccination strategies beyond infancy:: Recommendations by the global pertussis initiative
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DOI：
10.1086/426020
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发表时间：
2004-12-15
影响因子：
11.8
通讯作者：
Plotkin, S
中科院分区：
文献类型：
--
作者：
Forsyth, KD;Campins-Marti, M;Plotkin, S
背景全球百日咳倡议是一个专家科学论坛，旨在解决世界范围内与百日咳疾病相关的持续问题。该小组分析了百日咳疾病的发展趋势，提出了通过扩大疫苗接种策略改善疾病控制的建议，并提出了实施和支持研究活动的障碍的解决方案。百日咳杆菌感染是地方性的，在未接种疫苗或未完全接种疫苗的婴儿中仍然是一个严重的问题。此外，青少年和成年人百日咳发病率也在上升，他们不仅自身承受着相当大的健康负担，而且还会感染脆弱的婴儿。目前的疫苗接种战略需要加强。扩大疫苗接种应包括在现有儿童计划（学龄前或青少年）中增加加强剂量，并为传播B风险最高的特定成人亚组增加加强剂量。婴儿的百日咳感染（即，新生儿父母、新生儿的其他接触者和卫生保健工作者）。开展更多的流行病学研究、疾病传播研究和疫苗接种的成本效益研究将很有价值，而实施这些研究需要监测、改进诊断和开展教育运动。然而，作为普及成人疫苗接种的前奏，应在经济上可行的国家立即普及青少年疫苗接种。
Background. The Global Pertussis Initiative, an expert scientific forum, was established to address the ongoing problems associated with pertussis disease worldwide.Methods. The group analyzed pertussis disease trends, developed recommendations to improve disease control through expanded vaccination strategies, and proposed solutions to barriers to implementation and support of research activities.Results. Bordetella pertussis infection is endemic and continues to be a serious problem among unvaccinated or incompletely vaccinated infants. In addition, the reported incidence of pertussis disease is increasing in adolescents and adults, who not only experience a considerable health burden themselves but also infect vulnerable infants.Conclusions. Current vaccination strategies need to be reinforced. Expanded vaccination should include adding booster doses to existing childhood schedules (preschool or adolescent) and booster doses for those specific adult subgroups that have the highest risk of transmitting B. pertussis infection to infants (i.e., new parents, other contacts of newborns, and health care workers). More epidemiological studies and studies of disease transmission and the cost-effectiveness of vaccination would be valuable, and surveillance, diagnostic improvements, and educational campaigns are needed for implementation. However, as a prelude to universal adult vaccination, immediate universal adolescent vaccination should be instituted in countries in which it is economically feasible.