Grafting fetal suprachiasmatic nuclei in the hypothalamus of old hamsters restores responsiveness of the circadian clock to a phase shifting stimulus.
Grafting fetal suprachiasmatic nuclei in the hypothalamus of old hamsters restores responsiveness of the circadian clock to a phase shifting stimulus.
复制标题
将胎儿视交叉上核移植到老仓鼠的下丘脑中可以恢复生物钟对相移刺激的反应能力。
DOI：
10.1016/0006-8993(94)90044-2
复制
发表时间：
1994
期刊：
影响因子：
2.9
通讯作者：
Turek,FW
中科院分区：
文献类型：
--
作者：
VanReeth,O;Zhang,Y;Zee,PC;Turek,FW
在本研究中，在接受含有小脑组织或视交叉上核（SCN）的胎儿移植物之前和之后，对在恒定昏暗光线下自由奔跑的18-25个月大的仓鼠注射一定剂量的三唑仑，该剂量的三唑仑在已知的时间可靠地使年轻仓鼠的运动活动节律发生相移。SCN移植的动物，但不是对照动物植入胎儿小脑组织，表现出显着更大的反应，三唑仑的相移效应，表明至少有一些年龄相关的昼夜节律系统的变化可以逆转神经元移植。这些结果提出了一种可能性，即可以模拟胎儿SCN移植物的影响的神经药理学干预可能有助于治疗与年龄相关的昼夜节律功能障碍。
In the present study, 18–25-month-old hamsters free-running in constant dim light were injected, both before and after receiving fetal grafts containing either cerebellar tissue or the suprachiasmatic nuclei (SCN), with a dose of triazolam given at a time known to reliably phase shift the rhythm of locomotor activity in young hamsters. SCN-grafted animals, but not control animals implanted with fetal cerebellar tissue, showed a sifnificantly greater response to the phase shifting effects of triazolam, demonstrating that at least some age-related changes in the circadian system can be reversed by neuronal transplantation. These results raise the possibility that neuropharmacological interventions that can simulate the effects of fetal SCN grafts might be useful in the treatment of age-related disorders in circadian function.