Optical mapping of electrical activation in the developing heart.
Optical mapping of electrical activation in the developing heart.
复制标题
发育中心脏电激活的光学测绘。
DOI：
10.1017/s1431927605050452
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Thompson,RobertP
中科院分区：
文献类型：
--
作者：
Sedmera,David;Reckova,Maria;Rosengarten,Carlin;Torres,MariaI;Gourdie,RobertG;Thompson,RobertP
Specialized conduction tissues mediate coordinated propagation of electrical activity through the adult vertebrate heart. Following activation of the atria, the activation wave is slowed down in the atrioventricular canal or node, after which it spreads rapidly into the left and right ventricles via the His-Purkinje system (HPS). This results in the ventricles being activated from the apex toward the base, which is a hallmark of HPS function. The development of mature HPS function follows significant phases of cardiac morphogenesis. Initially, the cardiac impulse propagates in a slow, linear, and isotropic fashion from the sinus venosus at the most caudal portion of the tubular heart. Although the speed of impulse propagation gradually increases as it travels toward the anterior regions of the heart tube, the actual sequence of ventricular activation in the looped heart proceeds in the same direction as blood flow. Eventually, the immature base-to-apex sequence of ventricular activation undergoes an apparent reversal, changing to the mature apex-to-base pattern. Using an optical mapping approach, we demonstrate that the timing of this last transition shows striking dependence on hemodynamic loading of the ventricle, being accelerated by pressure overload and delayed in left ventricular hypoplasia. Comparison of chick and mammalian hearts revealed some striking similarities as well as key differences in the timing of such events during cardiac organogenesis.
