Burst-Modulated Waveforms Optimize Electrical Stimuli for Charge Efficiency and Fiber Selectivity
Burst-Modulated Waveforms Optimize Electrical Stimuli for Charge Efficiency and Fiber Selectivity
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DOI：
10.1109/tnsre.2015.2421732
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发表时间：
2015-11-01
影响因子：
4.9
通讯作者：
Irazoqui, Pedro P.
中科院分区：
文献类型：
--
作者：
Qing, Kurt Y.;Ward, Matthew P.;Irazoqui, Pedro P.
我们展示了一种设计电刺激的替代方法，称为突发调制，用于产生不同的神经纤维募集模式。通过以“脉冲子”微型脉冲的脉冲串而不是长的连续脉冲来传递电荷，我们的方法可以优化刺激效率和纤维选择性的波形。在我们的体内验证实验中，当用不同波形维持大鼠迷走神经的C纤维在近似50%的激活时，突发调制波形产生的A纤维激活比标准矩形脉冲波形少11%。（矩形：最大A反应的50.8 +/-1.5%，平均值的平均标准误差+/-脉冲串调制：39.8 +/-1.3%），这相当于A纤维反应幅度降低20%。此外，脉冲串调制波形需要每相少45%的刺激电荷以维持50%C纤维激活（矩形：20.7 +/-0.86 μ C;脉冲串调制：11.3 +/-0.41 μ C）。脉冲串调制波形在动物体内和动物之间产生了一致的纤维募集模式，这表明我们的刺激设计和响应分析方法提供了一种可靠的方法来研究神经刺激和提供治疗。
We demonstrate an alternative method of designing electrical stimuli-termed burst modulation for producing different patterns of nerve fiber recruitment. By delivering electrical charge in bursts of "pulsons" miniature pulses-instead of as long continuous pulses, our method can optimize the waveform for stimulation efficiency and fiber selectivity. In our in vivo validation experiments, while maintaining C fibers of the rat vagus nerve at similar to 50% activation with different waveforms, the burst-modulated waveform produced II% less A fiber activation than the standard rectangular pulse waveform (rectangular: 50.8 +/- 1.5% of maximal A response, mean standard error of the mean +/- burst-modulated: 39.8 +/- 1.3%), which equates to a 20% reduction in A fiber response magnitude. In addition, the burst-modulated waveform required 45% less stimulus charge per phase to maintain 50% C fiber activation (rectangular: 20.7 +/- 0.86 mu C; burst-modulated: 11.3 +/- 0.41 mu C). Burst-modulated waveforms produced consistent patterns of fiber recruitment within and across animals, which indicate that our methods of stimulus design and response analysis provide a reliable way to study neurostimulation and deliver therapy.