Intra-myocardial cusp waves and their manifestation in optical mapping signals.
Intra-myocardial cusp waves and their manifestation in optical mapping signals.
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心肌内尖波及其在光学映射信号中的表现。
DOI：
10.1109/iembs.2006.260852
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Pertsov,ArkadyM
中科院分区：
文献类型：
--
作者：
Bernus,Olivier;Zemlin,ChristianW;Matiukas,Arvydas;Hyatt,ChristopherJ;Pertsov,ArkadyM
心脏壁内的旋转纤维取向实质上影响电传播并且可以引起心肌内尖波。数值模拟表明，尖点形成在传播垂直于纤维取向的层中，并导致复杂的波前形态。它们可以穿越地层，并在外表面或内表面突破，在那里它们会引起明显的传播加速。这些结果的验证仍然是一个重大的实验挑战。在本研究中，我们调查如何计算和实验壁内尖波可以使用光学成像检测。我们的模拟表明，尖点改变光学上行程形态，并可以检测到它们到达表面之前（高达1毫米深）。Langendorff灌注豚鼠心脏的实验与我们的数值结果一致。
The rotating fiber orientation within the cardiac wall substantially affects the electrical propagation and can cause intra-myocardial cusp waves. Numerical simulations have shown that the cusps form in layers where propagation is perpendicular to the fiber orientation and lead to complex wave front morphologies. They can travel across layers and break through at the epi- or endocardial surfaces where they cause apparent accelerations of propagation. The validation of these results remains a major experimental challenge. In the present study, we investigate both computationally and experimentally how intramural cusp waves can be detected using optical imaging. Our simulations show that cusps alter the optical upstroke morphology and can be detected well before they reach the surface (up to 1 mm deep). Experiments in Langendorff-perfused guinea pig hearts are consistent with our numerical findings.