Getting into the brain: liposome-based strategies for effective drug delivery across the blood-brain barrier.
Getting into the brain: liposome-based strategies for effective drug delivery across the blood-brain barrier.
复制标题
深入大脑：基于脂质体的有效跨越血脑屏障的药物递送策略
DOI：
10.2147/ijn.s117210
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发表时间：
2016
影响因子：
8
通讯作者：
Gamarra LF
中科院分区：
文献类型：
--
作者：
Vieira DB;Gamarra LF
这篇综述总结了文献中报道的基于脂质体的策略，有效的药物输送通过血脑屏障。由于其独特的物理化学特性，脂质体已被广泛研究用于药物递送和体内生物成像，用于治疗和/或诊断神经系统疾病，如阿尔茨海默氏症、帕金森氏症、中风和神经胶质瘤。已经使用了几种策略来将药物和/或成像剂递送到大脑。肽、抗体和RNA适体等大分子的共价连接是受体靶向脂质体的有效方法，其允许其血脑屏障渗透和/或将其治疗分子特异性递送至疾病部位。此外，已经采用了用于开发可以响应外部刺激的脂质体的方法。可以得出结论，用于脑递送的脂质体的开发仍处于起步阶段，尽管这些系统具有彻底改变药物施用方式的潜力。
This review summarizes articles that have been reported in literature on liposome-based strategies for effective drug delivery across the blood–brain barrier. Due to their unique physicochemical characteristics, liposomes have been widely investigated for their application in drug delivery and in vivo bioimaging for the treatment and/or diagnosis of neurological diseases, such as Alzheimer’s, Parkinson’s, stroke, and glioma. Several strategies have been used to deliver drug and/or imaging agents to the brain. Covalent ligation of such macromolecules as peptides, antibodies, and RNA aptamers is an effective method for receptor-targeting liposomes, which allows their blood–brain barrier penetration and/or the delivery of their therapeutic molecule specifically to the disease site. Additionally, methods have been employed for the development of liposomes that can respond to external stimuli. It can be concluded that the development of liposomes for brain delivery is still in its infancy, although these systems have the potential to revolutionize the ways in which medicine is administered.