Competition Effects in Visual Cortex Between Emotional Distractors and a Primary Task in Remitted Depression.
Competition Effects in Visual Cortex Between Emotional Distractors and a Primary Task in Remitted Depression.
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DOI：
10.1016/j.bpsc.2016.12.007
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Gibb BE
中科院分区：
文献类型：
--
作者：
Woody ML;Miskovic V;Owens M;James KM;Feurer C;Sosoo EE;Gibb BE
注意偏差，特别是难以抑制对负面刺激的注意，与重度抑郁症（MDD）的风险有关。目前的研究使用连续的视觉皮层参与指数（稳态视觉诱发电位[SSVEPs]）在负性情绪诱导前后检测了注意偏倚的神经测量，这些负性情绪诱导是由于最近的MDD （rMDD）发作缓解而导致MDD复发的高危人群。此外，我们研究了工作记忆（WM）容量作为rMDD和视觉皮层反应之间联系的潜在调节因素。我们的样本包括27名患有rMDD的女性和28名从未抑郁过的女性。为了评估对情绪刺激的注意抑制，我们测量了由空间叠加的任务相关刺激和以不同频率振荡的情绪干扰（情绪的面部表现）诱发的频率标记的ssvep。在视觉空间记忆任务中评估WM能力。与从未抑郁过的女性相比，患有rMDD的女性在负面情绪诱导前难以抑制对所有情绪干扰物的注意力，对负面干扰物（悲伤的脸）的影响最大。在情绪诱导之后，rMDD女性对情绪干扰物的注意力基本保持不变。在rMDD的女性中，较低的WM能力预示着更大的困难抑制对消极和中性干扰物的注意。通过利用视觉皮层的振荡共振现象，我们追踪了不同效价的空间叠加刺激在神经反应中的竞争。结果表明，患有rMDD的女性对情绪干扰物的注意抑制受损，与状态情绪无关，这种偏见在WM能力较低的女性中表现得最为明显。
Attentional biases, particularly difficulty inhibiting attention to negative stimuli, are implicated in risk for major depressive disorder (MDD). The current study examined a neural measure of attentional bias using a continuous index of visuocortical engagement (steady-state visual evoked potentials [SSVEPs]) before and after a negative mood induction in a population at high-risk for MDD recurrence due to a recently remitted MDD (rMDD) episode. Additionally, we examined working memory (WM) capacity as a potential moderator of the link between rMDD and visuocortical responses. Our sample consisted of 27 women with rMDD and 28 never-depressed women. To assess attentional inhibition to emotional stimuli, we measured frequency-tagged SSVEPs evoked from spatially superimposed task-relevant stimuli and emotional distractors (facial displays of emotion) oscillating at distinct frequencies. WM capacity was assessed during a visuospatial memory task. Women with rMDD, relative to never-depressed women, displayed difficulty inhibiting attention to all emotional distractors before a negative mood induction, with the strongest effect for negative distractors (sad faces). Following the mood induction, rMDD women’s attention to emotional distractors remained largely unchanged. Among women with rMDD, lower WM capacity predicted greater difficulty inhibiting attention to negative and neutral distractors. By exploiting the phenomenon of oscillatory resonance in the visual cortex, we tracked competition in neural responses for spatially superimposed stimuli differing in valence. Results demonstrated that women with rMDD display impaired attentional inhibition of emotional distractors independent of state mood and that this bias is strongest among those with lower WM capacity.
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影响因子：
6.9
作者：
Fritzsche, A.;Dahme, B.;Gotlib, I. H.;Joormann, J.;Magnussen, H.;Watz, H.;Nutzinger, D. O.;von Leupoldt, A.
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