Fibrin-targeted block copolymers for the prevention of postsurgical adhesions.
Fibrin-targeted block copolymers for the prevention of postsurgical adhesions.
复制标题
用于预防术后粘连的纤维蛋白靶向嵌段共聚物。
DOI：
10.1002/jbm.b.31876
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Dziubla,ThomasD
中科院分区：
文献类型：
--
作者：
Medley,JohnM;Kaplan,Eugene;Oz,HeliehS;Sundararaj,SharathC;Puleo,DavidA;Dziubla,ThomasD
尽管手术方法取得了进步，但手术后粘连(PSA)仍然是一个重大的临床挑战，每年影响数百万患者。组织之间的这些永久性纤维连接是由扩展的纤维蛋白凝胶基质(FGM)连接损伤内表面的结果。粘连的形成是创伤愈合途径在系统水平上汇聚的结果，使可以抑制粘连发生的材料的设计复杂化。在这项研究中，使用一种系统的方法来确定功能性能优化所需的关键材料属性，以设计一种新的以纤维蛋白为靶点的PSA预防材料。合成了一系列具有不同分子结构的多功能聚合物，研究了改变聚合物结构参数对破坏延伸功能梯度材料形成能力的影响。在小鼠粘连模型中的初步研究表明，PSA的形成程度在统计上显著降低，证明了这种系统方法的潜在价值。《生物材料资源》第B部分：APPL Biomater，2011。
Despite advances in surgical methods, postsurgical adhesions (PSA) remain a significant clinical challenge affecting millions of patients each year. These permanent fibrous connections between tissues result from the bridging of wounded internal surfaces by an extended fibrin gel matrix (FGM). Adhesion formation is a result of a systems level convergence of wound healing pathways, complicating the design of materials that could inhibit their occurrence. In this study, a systematic approach that identifies key material properties required for functional performance optimization was used to design a new fibrin‐targeted PSA prevention material. A series of multifunctional polymers with varied molecular architectures was synthesized to investigate the effect of changing polymer structural parameters on the ability to disrupt the formation of an extended FGM. Initial studies in a murine adhesion model demonstrated a statistically significant reduction in the degree of PSA formation, demonstrating the potential value of this systematic approach. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.