Inflammation and dementia: epidemiologic evidence
Inflammation and dementia: epidemiologic evidence
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DOI：
10.1111/j.1600-0404.2006.00693.x
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发表时间：
2006-01-01
影响因子：
3.5
通讯作者：
Launer, L. J.
中科院分区：
文献类型：
--
作者：
Peila, R.;Launer, L. J.
基于实验和神经病理学研究，炎症被假定在导致神经变性以及血管损伤的过程中起核心作用。为了更好地了解炎症在认知障碍（CD）中的作用，识别CD的潜在生物标志物，并选择可能对CD具有遗传易感性的个体，在CD的流行病学研究中采用了几种不同的炎症指标，本文综述了非甾体抗炎药的负相关性。药物一直被报道。关于细胞因子的各种血清标志物与CD的相关性的报告更具可变性。有几个流行病学研究已经检查了CD和单核苷酸多态性（SNP）调节细胞因子的关联，虽然这些已经在临床病例对照系列中进行了检查。总结了来自檀香山亚洲老龄化研究的白细胞介素-I SNP相关性的数据。关于炎症在CD中的作用以及如何在基于人群的研究中最好地测量它，有许多悬而未决的问题。
Based on experimental and neuropathologic studies, inflammation is postulated to play a central role in processes leading to neurodegeneration as well as vascular injury. To better understand the role of inflammation in cognitive disorders (CD), identify potential biomarkers for CD, and select individuals who may have a genetic susceptibility to CD, several different measures of inflammation have been employed in epidemiologic studies of CD, which are reviewed An inverse association of non-steroidal anti-inflammatory here. medications has been consistently reported. More variable are reports on the associations of various serum markers of cytokines to CD. There are few epidemiologic studies that have examined the association of CD and single nucleotide polymorphisms (SNP) regulating cytokines, although these have been examined in clinical case-control series. Data are summarized on the association of interleukin-I SNPs from the Honolulu Asia Aging Study. There are many outstanding questions about the role of inflammation in CD and how best to measure it in the context of population-based studies.